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• W3173239241 abstract "Cutaneous T-cell lymphomas (CTCLs) comprise a group of heterogeneous diseases involving malignant T cells. The pathogenesis and etiology of CTCL are still unclear, although a large number of genetic and epidemiological studies on CTCL have been conducted. Most CTCLs have an indolent course, making early diagnosis difficult. Once large-cell transformation occurs, CTCL progresses to more aggressive types, resulting in an overall survival of less than five years. Epigenetic drugs, which have shown certain curative effects, have been selected as third-line drugs in patients with relapsing and refractory CTCL. Many studies have also identified epigenetic biomarkers from tissues and peripheral blood of patients with CTCL and suggested that epigenetic changes play a role in malignant transformation and histone deacetylase inhibitor (HDACi) resistance in CTCL. Single-cell sequencing has been applied in CTCL studies, revealing heterogeneity in CTCL malignant T cells. The mechanisms of HDACi resistance have also been described, further facilitating the discovery of novel HDACi targets. Despite the heterogeneity of CTCL disease and its obscure pathogenesis, more epigenetic abnormalities have been gradually discovered recently, which not only enables us to understand CTCL disease further but also improves our understanding of the specific role of epigenetics in the pathogenesis and treatment. In this review, we discuss the recent discoveries concerning the pathological roles of epigenetics and epigenetic therapy in CTCL." @default.
• W3173239241 created "2021-07-05" @default.
• W3173239241 creator A5019544133 @default.
• W3173239241 creator A5055151897 @default.
• W3173239241 date "2021-06-24" @default.
• W3173239241 modified "2023-10-10" @default.
• W3173239241 title "Epigenetics in the Pathogenesis and Treatment of Cutaneous T-Cell Lymphoma" @default.
• W3173239241 cites W1481966521 @default.
• W3173239241 cites W1529783573 @default.
• W3173239241 cites W1877715550 @default.
• W3173239241 cites W1966025067 @default.
• W3173239241 cites W1967615841 @default.
• W3173239241 cites W1968568016 @default.
• W3173239241 cites W1970419045 @default.
• W3173239241 cites W1975095019 @default.
• W3173239241 cites W1978479182 @default.
• W3173239241 cites W1979420316 @default.
• W3173239241 cites W1984205120 @default.
• W3173239241 cites W1984342174 @default.
• W3173239241 cites W1987077240 @default.
• W3173239241 cites W1990229157 @default.
• W3173239241 cites W1992318396 @default.
• W3173239241 cites W1993366417 @default.
• W3173239241 cites W1994198833 @default.
• W3173239241 cites W1995199440 @default.
• W3173239241 cites W2000406589 @default.
• W3173239241 cites W2007877648 @default.
• W3173239241 cites W2014203129 @default.
• W3173239241 cites W2018775994 @default.
• W3173239241 cites W2027288274 @default.
• W3173239241 cites W2030822086 @default.
• W3173239241 cites W2037920224 @default.
• W3173239241 cites W2043916755 @default.
• W3173239241 cites W2045009458 @default.
• W3173239241 cites W2051767126 @default.
• W3173239241 cites W2051890772 @default.
• W3173239241 cites W2053344100 @default.
• W3173239241 cites W2057358066 @default.
• W3173239241 cites W2059489068 @default.
• W3173239241 cites W2061152470 @default.
• W3173239241 cites W2065882807 @default.
• W3173239241 cites W2069484207 @default.
• W3173239241 cites W2071115015 @default.
• W3173239241 cites W2071854923 @default.
• W3173239241 cites W2084393474 @default.
• W3173239241 cites W2086172317 @default.
• W3173239241 cites W2086780062 @default.
• W3173239241 cites W2093918575 @default.
• W3173239241 cites W2096221424 @default.
• W3173239241 cites W2101386968 @default.
• W3173239241 cites W2102169774 @default.
• W3173239241 cites W2104535331 @default.
• W3173239241 cites W2109404758 @default.
• W3173239241 cites W2110957729 @default.
• W3173239241 cites W2131233619 @default.
• W3173239241 cites W2142878395 @default.
• W3173239241 cites W2147246240 @default.
• W3173239241 cites W2149742288 @default.
• W3173239241 cites W2153225767 @default.
• W3173239241 cites W2156517973 @default.
• W3173239241 cites W2156952099 @default.
• W3173239241 cites W2164514428 @default.
• W3173239241 cites W2166319541 @default.
• W3173239241 cites W2167841359 @default.
• W3173239241 cites W2171365282 @default.
• W3173239241 cites W2174515690 @default.
• W3173239241 cites W2187055065 @default.
• W3173239241 cites W2195886524 @default.
• W3173239241 cites W2227818952 @default.
• W3173239241 cites W2271138696 @default.
• W3173239241 cites W2274163145 @default.
• W3173239241 cites W2275989822 @default.
• W3173239241 cites W2319957331 @default.
• W3173239241 cites W2329193263 @default.
• W3173239241 cites W2336180607 @default.
• W3173239241 cites W2344408938 @default.
• W3173239241 cites W2461455421 @default.
• W3173239241 cites W2465767363 @default.
• W3173239241 cites W2509004978 @default.
• W3173239241 cites W2522828783 @default.
• W3173239241 cites W2543207398 @default.
• W3173239241 cites W2593928664 @default.
• W3173239241 cites W2625424984 @default.
• W3173239241 cites W2626800051 @default.
• W3173239241 cites W2698893522 @default.
• W3173239241 cites W2709898312 @default.
• W3173239241 cites W2735212662 @default.
• W3173239241 cites W2736055102 @default.
• W3173239241 cites W2736287079 @default.
• W3173239241 cites W2753015461 @default.
• W3173239241 cites W2761666143 @default.
• W3173239241 cites W2761708088 @default.
• W3173239241 cites W2775032181 @default.
• W3173239241 cites W2793709937 @default.
• W3173239241 cites W2802898289 @default.
• W3173239241 cites W2883902424 @default.
• W3173239241 cites W2884131848 @default.
• W3173239241 cites W2885239461 @default.
• W3173239241 cites W2889409170 @default.
• W3173239241 cites W2889602315 @default.

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