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- W3173261305 startingPage "365" @default.
- W3173261305 abstract "Glioblastoma (GBM) is the most lethal form of brain cancer. To date, no therapy exists to save patients from this deadly disease. Even though most of the patients subjected to surgical resection followed by radiotherapy and chemotherapy undergo remission, the tumor always recurs, leading to death in 15 months from diagnosis. Besides the blood-brain barrier (BBB), which represents a first-line shield from therapeutic molecules, GBM exploits a plethora of extracellular, cellular, and molecular weapons to escape therapy, either by hindering the drug uptake or by overriding its toxic effect. GBM stem cells (GSCs) are not only the hub of tumor initiation but also the immortal fuel of chemoresistance, owing to their innate and acquired molecular equipment. Therefore, the molecular mechanisms responsible for GSC chemoresistance have attracted the interest of scientists for their potential therapeutic applications. The scenario, however, appears very complex, since chemoresistance is not only attributable to GSCs, but also to other cellular mechanisms, such as the transformation of proneural and endothelial cells into mesenchymal stem cells. Moreover, the involved molecular mechanisms foresee the expression of efflux transporters, the activation of DNA repair mechanisms (such as O 6 -methylguanine-DNA methyl-transferase, base excision repair, mismatch repair), metabolic switching, autophagy, and depends on the expression of several genes. On the other hand, a pivotal role is played by extracellular mechanisms, involving the BBB, tumor microenvironment, and immunologic resistance." @default.
- W3173261305 created "2021-07-05" @default.
- W3173261305 creator A5071286934 @default.
- W3173261305 creator A5073106824 @default.
- W3173261305 date "2021-01-01" @default.
- W3173261305 modified "2023-10-16" @default.
- W3173261305 title "Molecular and cellular mechanisms in recurrent glioblastoma chemoresistance" @default.
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