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- W3173275598 endingPage "3731" @default.
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- W3173275598 abstract "Folates have a pterine core structure and high metabolic activity due to their ability to accept electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential one-carbon pathways donating methyl-groups to choline phospholipids, creatine, epinephrine, DNA. Compounds similar to folates are ubiquitous and have been found in different animals, plants, and microorganisms. Folates enter the body from the diet and are also synthesized by intestinal bacteria with consequent adsorption from the colon. Three types of folate and antifolate cellular transporters have been found, differing in tissue localization, substrate affinity, type of transferring, and optimal pH for function. Laboratory criteria of folate deficiency are accepted by WHO. Severe folate deficiencies, manifesting in early life, are seen in hereditary folate malabsorption and cerebral folate deficiency. Acquired folate deficiency is quite common and is associated with poor diet and malabsorption, alcohol consumption, obesity, and kidney failure. Given the observational data that folates have a protective effect against neural tube defects, ischemic events, and cancer, food folic acid fortification was introduced in many countries. However, high physiological folate concentrations and folate overload may increase the risk of impaired brain development in embryogenesis and possess a growth advantage for precancerous altered cells." @default.
- W3173275598 created "2021-07-05" @default.
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- W3173275598 date "2021-06-18" @default.
- W3173275598 modified "2023-10-17" @default.
- W3173275598 title "The Concept of Folic Acid in Health and Disease" @default.
- W3173275598 cites W12049018 @default.
- W3173275598 cites W1414459154 @default.
- W3173275598 cites W1467952179 @default.
- W3173275598 cites W1527500190 @default.
- W3173275598 cites W1529220262 @default.
- W3173275598 cites W1543288352 @default.
- W3173275598 cites W1557687412 @default.
- W3173275598 cites W1573805404 @default.
- W3173275598 cites W1590031600 @default.
- W3173275598 cites W1597619535 @default.
- W3173275598 cites W1635858395 @default.
- W3173275598 cites W1766248388 @default.
- W3173275598 cites W1902173288 @default.
- W3173275598 cites W1903238701 @default.
- W3173275598 cites W1957147349 @default.
- W3173275598 cites W1963776452 @default.
- W3173275598 cites W1964870771 @default.
- W3173275598 cites W1968051127 @default.
- W3173275598 cites W1968627984 @default.
- W3173275598 cites W1969552935 @default.
- W3173275598 cites W1970218983 @default.
- W3173275598 cites W1970451217 @default.
- W3173275598 cites W1970512925 @default.
- W3173275598 cites W1971341208 @default.
- W3173275598 cites W1971580188 @default.
- W3173275598 cites W1975066367 @default.
- W3173275598 cites W1975357252 @default.
- W3173275598 cites W1977866186 @default.
- W3173275598 cites W1978177158 @default.
- W3173275598 cites W1979539710 @default.
- W3173275598 cites W1980773456 @default.
- W3173275598 cites W1981271620 @default.
- W3173275598 cites W1981947598 @default.
- W3173275598 cites W1982590258 @default.
- W3173275598 cites W1987905087 @default.
- W3173275598 cites W1988172699 @default.
- W3173275598 cites W1989203203 @default.
- W3173275598 cites W1992593557 @default.
- W3173275598 cites W1993354505 @default.
- W3173275598 cites W1995967787 @default.
- W3173275598 cites W1998418923 @default.
- W3173275598 cites W2002038028 @default.
- W3173275598 cites W2002583208 @default.
- W3173275598 cites W2005564022 @default.
- W3173275598 cites W2006752058 @default.
- W3173275598 cites W2009193838 @default.
- W3173275598 cites W2011006722 @default.
- W3173275598 cites W2014165277 @default.
- W3173275598 cites W2015006203 @default.
- W3173275598 cites W2019040698 @default.
- W3173275598 cites W2023452084 @default.
- W3173275598 cites W2024128262 @default.
- W3173275598 cites W2025660630 @default.
- W3173275598 cites W2026641087 @default.
- W3173275598 cites W2027004900 @default.
- W3173275598 cites W2027126829 @default.
- W3173275598 cites W2028776386 @default.
- W3173275598 cites W2030073764 @default.
- W3173275598 cites W2030839553 @default.
- W3173275598 cites W2031073211 @default.
- W3173275598 cites W2036171577 @default.
- W3173275598 cites W2036935674 @default.
- W3173275598 cites W2037260804 @default.
- W3173275598 cites W2038931392 @default.
- W3173275598 cites W2040175155 @default.
- W3173275598 cites W2040750819 @default.
- W3173275598 cites W2041148908 @default.
- W3173275598 cites W2045474280 @default.
- W3173275598 cites W2045543458 @default.
- W3173275598 cites W2051446073 @default.
- W3173275598 cites W2053679855 @default.
- W3173275598 cites W2053917340 @default.
- W3173275598 cites W2060459188 @default.
- W3173275598 cites W2062630004 @default.
- W3173275598 cites W2063431146 @default.
- W3173275598 cites W2064384617 @default.
- W3173275598 cites W2067720409 @default.
- W3173275598 cites W2067848116 @default.
- W3173275598 cites W2070009272 @default.
- W3173275598 cites W2074092968 @default.
- W3173275598 cites W2076608291 @default.
- W3173275598 cites W2080225664 @default.
- W3173275598 cites W2084201616 @default.