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- W3173303921 abstract "In this paper, we show that the essential Hsp90 co-chaperone Sgt1 is a member of a general protein quality control network that links folding and degradation through its participation in the degradation of misfolded proteins both in the cytosol and the endoplasmic reticulum (ER). Sgt1-dependent protein degradation acts in a parallel pathway to the ubiquitin ligase (E3) and ubiquitin chain elongase (E4), Hul5, and overproduction of Hul5 partly suppresses defects in cells with reduced Sgt1 activity. Upon proteostatic stress, Sgt1 accumulates transiently, in an Hsp90- and proteasome-dependent manner, with quality control sites (Q-bodies) of both yeast and human cells that co-localize with Vps13, a protein that creates organelle contact sites. Misfolding disease proteins, such as synphilin-1 involved in Parkinson's disease, are also sequestered to these compartments and require Sgt1 for their clearance." @default.
- W3173303921 created "2021-07-05" @default.
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- W3173303921 creator A5060274588 @default.
- W3173303921 date "2021-06-01" @default.
- W3173303921 modified "2023-09-23" @default.
- W3173303921 title "An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality control" @default.
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- W3173303921 cites W1971694393 @default.
- W3173303921 cites W1973205231 @default.
- W3173303921 cites W1976980123 @default.
- W3173303921 cites W1977733856 @default.
- W3173303921 cites W1980144454 @default.
- W3173303921 cites W1994300141 @default.
- W3173303921 cites W1996615076 @default.
- W3173303921 cites W2006447117 @default.
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- W3173303921 cites W2023158097 @default.
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- W3173303921 cites W2049656093 @default.
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- W3173303921 cites W2074273512 @default.
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- W3173303921 cites W2189788457 @default.
- W3173303921 cites W2216761081 @default.
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- W3173303921 cites W2292412857 @default.
- W3173303921 cites W2411562838 @default.
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- W3173303921 cites W2492182430 @default.
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- W3173303921 doi "https://doi.org/10.1016/j.celrep.2021.109328" @default.
- W3173303921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34192536" @default.
- W3173303921 hasPublicationYear "2021" @default.
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