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- W3173309086 abstract "Cytokine release syndrome (CRS) remains a significant toxicity of chimeric antigen receptor T-cell (CAR-T) therapy for hematologic malignancies. While established guidelines exist for the management of Grade 2+ CRS with immunosuppressive agents such as tocilizumab or corticosteroids, the management of early-grade CRS (i.e. Grade 1 CRS with isolated fevers) has no such consensus beyond supportive care. In this review, we discuss early-grade CRS with an emphasis on its diagnosis, management, and prevention. Strategies to target early-grade CRS include immunosuppression preemptively (once CRS develops) or prophylactically (before CRS develops) as well as novel small-molecule inhibitors or fractionated CAR-T dosing. In the near future, next-generation CAR-T therapies may be able to target CRS precisely or obviate CRS entirely. If shown to prevent CRS-associated morbidity while maintaining therapeutic anti-neoplastic efficacy, these innovative strategies will enhance the safety of CAR-T therapy while also improving its operationalization and accessibility in the real-world setting." @default.
- W3173309086 created "2021-07-05" @default.
- W3173309086 creator A5022331310 @default.
- W3173309086 creator A5053904944 @default.
- W3173309086 creator A5082487188 @default.
- W3173309086 date "2021-06-21" @default.
- W3173309086 modified "2023-09-24" @default.
- W3173309086 title "Toci or not toci: innovations in the diagnosis, prevention, and early management of cytokine release syndrome" @default.
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