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- W3173313191 abstract "Recent evidence suggests a protective role of ANP in myocardial infarction, although the underlying mechanism whereby ANP exerts its cardioprotection is not fully understood. Our preliminary data have shown that ischemia/reperfusion (I/R) injury in ANP-/- mice resulted in an increase in mortality as compared with wide-type ANP+/+ mice, supporting a cardioprotective role of ANP. In this experiment, we sought to determine the effect of ANP gene disruption on expression of immediate-early response (cFOS, cJUN), inflammatory (IL-6), and apoptotic (Bcl-2, BAX) genes. Ischemia (1 hr)/reperfusion (24 hr) injury was induced by ligation of the anterior interventricular branch of the left coronary artery (LAD) and real-time PCR was used to quantify gene expression. Our data indicate that in response to I/R injury, ANP-/- mice expressed significantly higher levels of BNP, cJUN and IL-6 than that of the ANP+/+ mice. Expression of Bcl-2 and BAX genes remain unchanged in the groups studied. These results suggest that the ANP-/- mice over-expressed BNP in an attempt to overcome the lack of ANP expression in response to I/R insult. Over-expression of cJUN and IL-6 genes may be responsible for the inability of ANP-/- mice to protect the heart against I/R injury. Surprisingly there is no change in the expression of Bcl-2 and BAX genes 24 hours following I/R injury, although it is possible that over-expression of these apoptotic genes may come at a later time point. (Supported by Heart and Stroke Foundation of Ontario and the CIHR)" @default.
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- W3173313191 date "2007-01-01" @default.
- W3173313191 modified "2023-09-26" @default.
- W3173313191 title "Alterations of gene expression in the heart of atrial natriuretic peptide gene‐disrupted (ANP‐/‐) mice following ischemia/reperfusion injury" @default.
- W3173313191 doi "https://doi.org/10.1096/fasebj.21.6.a973-d" @default.
- W3173313191 hasPublicationYear "2007" @default.
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