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- W3173317172 abstract "When the contents of the bloodstream are filtered by the kidney, glucose is reabsorbed. Familial glycosuria, a benign disorder often attributed to genetic variants in the gene SLC5A2 which encodes the protein Sodium Glucose Transporter 2 (SGLT2), prevents reabsorption of glucose leading to an excess amount in urine. SGLT2 is used for glucose reabsorption, and when functioning properly, about 90% of glucose from the urine is reabsorbed into the bloodstream. Upon glucose and sodium binding, SGLT2 undergoes a conformational change, where the structure shifts from an outward to an inward facing orientation, allowing glucose to be released. Recently, two novel variants in SLC5A2 have been identified in the Marshfield Clinic patient population; further research is being conducted to determine whether these variants impact glucose transportation and how they affect physiological output. To research this, homology models of WT SGLT2 were constructed and analyzed based on a previously solved structure of a bacterial SGLT protein (vSGLT). It can be concluded that SGLT2's structure is composed of 14 transmembrane helices which surround both galactose/glucose and sodium binding sites. Recently, SGLT2 has become a popular target for Type II diabetes therapeutics. These drugs inhibit SGLT2, as they prevent glucose to be reabsorbed; thus, glucose is excreted out of the body. Further understanding how genetic variants effect SGLT2 structure and function may allow practitioners to properly prescribe medications and prevent adverse drug reactions when treating patients with Type II diabetes. Support or Funding Information Marshfield Clinic Research Foundation This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
- W3173317172 created "2021-07-05" @default.
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- W3173317172 date "2018-04-01" @default.
- W3173317172 modified "2023-09-26" @default.
- W3173317172 title "The Use of Pharmacogenetics in Targeting SGLT2 and its Variants" @default.
- W3173317172 doi "https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb199" @default.
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