Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173321622> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3173321622 abstract "The stimulation of PL with acetylcholine (ACh) caused depressor response mediated by muscarinic receptors. Studies in literature demonstrated that stimulation of muscarinic receptors induced cyclic GMP formation mediated by nitric oxide. Hence, the objective of this study was to investigate if cardiovascular response caused by muscarinic receptors stimulation is mediated by nitric oxide and cyclic GMP formation. Male Wistar rats (240–280g) were used and guide cannulae were implanted in the PL for drug injection. The cardiovascular responses evoked by ACh (30nmol/200nL) microinjected into the PL were measured before and 15 min after PL treatment with, J 104129 fumarate - M3 antagonist (6nmol/200nL), pirenzepine - M1 antagonist (6nmol/200nL), N-Propyl - inhibitor of neuronal nitric oxide synthase (nNOS) (0,04nmol/200nL), carboxy-PTIO - scavenger NO (1nmol/200nL) or ODQ - guanylate cyclase inhibitor (1nmol/200nL). A polyethylene catheter was implanted in the femoral artery for MAP and HR records. The statistical test utilized was two-way ANOVA. The pre-treatment with pirenzepine did not blockade the decrease of the MAP (F1,220=6.526; P=0.0113) and increase of the HR (F1,220=0.2313; P=0.6310), while J 104129 fumarate (MAP: F1,220=200.7; P<0.0001; HR: F1,220=170.1; P<0.0001), N-Propyl (MAP: F1,264=79.04; P<0.0001; HR: F1,264=257.4; P<0.0001), C-PTIO (MAP: F1,176=115.4; P<0.0001; HR: F1,176=255.7; P<0.0001) or ODQ (MAP: F1,220=165.7; P<0.0001; HR: F1,220=161.3; P<0.0001) blocked depressor and tachycardic responses caused by ACh microinjection into the PL. This results demonstrated that the cardiovascular responses caused by ACh in PL are mediated by local nitric oxide – guanylate cyclase mechanism. Financial Support: CAPES and FAEPA." @default.
- W3173321622 created "2021-07-05" @default.
- W3173321622 creator A5023321407 @default.
- W3173321622 creator A5025372783 @default.
- W3173321622 creator A5050563382 @default.
- W3173321622 creator A5057549473 @default.
- W3173321622 creator A5069696318 @default.
- W3173321622 date "2013-04-01" @default.
- W3173321622 modified "2023-09-23" @default.
- W3173321622 title "Cardiovascular responses evoked by acetylcholine in prelimbic cortex is mediated by nitric oxide – guanylate cyclase mechanism in rats" @default.
- W3173321622 doi "https://doi.org/10.1096/fasebj.27.1_supplement.654.14" @default.
- W3173321622 hasPublicationYear "2013" @default.
- W3173321622 type Work @default.
- W3173321622 sameAs 3173321622 @default.
- W3173321622 citedByCount "0" @default.
- W3173321622 crossrefType "journal-article" @default.
- W3173321622 hasAuthorship W3173321622A5023321407 @default.
- W3173321622 hasAuthorship W3173321622A5025372783 @default.
- W3173321622 hasAuthorship W3173321622A5050563382 @default.
- W3173321622 hasAuthorship W3173321622A5057549473 @default.
- W3173321622 hasAuthorship W3173321622A5069696318 @default.
- W3173321622 hasConcept C121684516 @default.
- W3173321622 hasConcept C126322002 @default.
- W3173321622 hasConcept C134018914 @default.
- W3173321622 hasConcept C170493617 @default.
- W3173321622 hasConcept C185592680 @default.
- W3173321622 hasConcept C207723603 @default.
- W3173321622 hasConcept C24998067 @default.
- W3173321622 hasConcept C2775910092 @default.
- W3173321622 hasConcept C2776885963 @default.
- W3173321622 hasConcept C2777622882 @default.
- W3173321622 hasConcept C2778616617 @default.
- W3173321622 hasConcept C2778938600 @default.
- W3173321622 hasConcept C2779997099 @default.
- W3173321622 hasConcept C33789571 @default.
- W3173321622 hasConcept C41008148 @default.
- W3173321622 hasConcept C519581460 @default.
- W3173321622 hasConcept C71924100 @default.
- W3173321622 hasConcept C98274493 @default.
- W3173321622 hasConceptScore W3173321622C121684516 @default.
- W3173321622 hasConceptScore W3173321622C126322002 @default.
- W3173321622 hasConceptScore W3173321622C134018914 @default.
- W3173321622 hasConceptScore W3173321622C170493617 @default.
- W3173321622 hasConceptScore W3173321622C185592680 @default.
- W3173321622 hasConceptScore W3173321622C207723603 @default.
- W3173321622 hasConceptScore W3173321622C24998067 @default.
- W3173321622 hasConceptScore W3173321622C2775910092 @default.
- W3173321622 hasConceptScore W3173321622C2776885963 @default.
- W3173321622 hasConceptScore W3173321622C2777622882 @default.
- W3173321622 hasConceptScore W3173321622C2778616617 @default.
- W3173321622 hasConceptScore W3173321622C2778938600 @default.
- W3173321622 hasConceptScore W3173321622C2779997099 @default.
- W3173321622 hasConceptScore W3173321622C33789571 @default.
- W3173321622 hasConceptScore W3173321622C41008148 @default.
- W3173321622 hasConceptScore W3173321622C519581460 @default.
- W3173321622 hasConceptScore W3173321622C71924100 @default.
- W3173321622 hasConceptScore W3173321622C98274493 @default.
- W3173321622 hasIssue "S1" @default.
- W3173321622 hasLocation W31733216221 @default.
- W3173321622 hasOpenAccess W3173321622 @default.
- W3173321622 hasPrimaryLocation W31733216221 @default.
- W3173321622 hasRelatedWork W1878792646 @default.
- W3173321622 hasRelatedWork W1964698960 @default.
- W3173321622 hasRelatedWork W2037916552 @default.
- W3173321622 hasRelatedWork W2053275567 @default.
- W3173321622 hasRelatedWork W2071774153 @default.
- W3173321622 hasRelatedWork W2075290087 @default.
- W3173321622 hasRelatedWork W2079867054 @default.
- W3173321622 hasRelatedWork W2094064741 @default.
- W3173321622 hasRelatedWork W2177951135 @default.
- W3173321622 hasRelatedWork W2187141558 @default.
- W3173321622 hasVolume "27" @default.
- W3173321622 isParatext "false" @default.
- W3173321622 isRetracted "false" @default.
- W3173321622 magId "3173321622" @default.
- W3173321622 workType "article" @default.