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- W3173396924 abstract "We evaluated single-pass pulmonary neutrophil kinetics using the multiple indicator-dilution technique in control pigs (n = 10), after sternotomy alone (sterno, n = 10) or after 30 min of observation following a period of 90 min extracorporeal circulation (n = 7). Blood neutrophils increased in the control and sterno groups (p < 0.05) but remained unchanged in the extracorporeal circulation group. The transfer coefficient for neutrophil margination from the circulating to the lung-marginated pool (kc-m) and pulmonary neutrophil clearance (Clc-m) were similar between the three groups. There was an inverse correlation between kc-m and the degree of lung tissue perfusion evaluated form the tracer-accessible extravascular lung water (r = −0.54, p < 0.01). There was no arterio-venous gradient of neutrophils in any of the groups, suggesting a dynamic equilibrium of the margination/demargination processes. We conclude that extracorporeal circulation does not significantly modify single pass pulmonary neutrophil kinetics 30 min after reperfusion. The rate of neutrophil margination to the tracer-accessible lung tissue suggests that lung tissue derecruitment is associated with increased neutrophil margination. This work was supported by the Heart and Stroke Foundation of Canada and the “Fondation de l’Institut de Cardiologie de Montréal”. Dr. Dupuis is a senior scholar of the “Fonds de la recherche en santé du Québec”." @default.
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- W3173396924 date "2006-03-01" @default.
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- W3173396924 title "Effect of sternotomy and extracorporeal circulation on pulmonary neutrophil kinetics in pigs" @default.
- W3173396924 doi "https://doi.org/10.1096/fasebj.20.4.a282-c" @default.
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