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- W3173414235 abstract "The present work describes the design, synthesis, and evaluation of the anticancer properties of pyrazolone ring appended triarylmethanes by the condensation of diarylmethanols with pyrazolone in presence of a catalytic amount of p-TSA catalyst. The use of an inexpensive catalyst and accessing the desired product in good yields within a short span are the merits associated with this protocol. Furthermore, the in-silico, as well as in-vitro analysis and molecular docking of the designed molecules, were performed followed by their anticancer activity evaluation against cancer cell lines like MCF7, MDA-MB-231, HeLa, and DU-145. Few of the synthesized molecules demonstrated significant anticancer activity and could provide a new direction in the development of anti-cancer molecules." @default.
- W3173414235 created "2021-07-05" @default.
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- W3173414235 date "2021-06-25" @default.
- W3173414235 modified "2023-10-16" @default.
- W3173414235 title "Synthesis and Evaluation of Anticancer Activity of Pyrazolone Appended Triarylmethanes (TRAMs)" @default.
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- W3173414235 doi "https://doi.org/10.1002/slct.202101083" @default.
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