Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173428488> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W3173428488 abstract "Objective Sickle cell disease (SCD) is a complex hereditary blood disorder that can significantly affect the rheological properties of patients. Researches on the change of the rheological properties of blood and hemodynamics in a single capillary vessel have been carried out in recent three decades. The target of this work is to explore the hemodynamic behavior of diseased capillary networks based on anatomical data, in order to provide advice on the generation and prevention of the vaso-occlusive crisis of patients with sickle cell disease. Method In this work, we use numerical simulations to calculate the sickle RBC velocity, blood hematocrit and blood viscosity in capillary bifurcations and networks based on mesenteric anatomical data. Then, the model predictions are discussed with reported clinical manifestations and compared with normal networks. Results The predictions from our simulations show agreement with clinical manifestations. Compared with the properties of normal capillary networks, the blood flow in diseased micro vessel networks has 10%–25% larger hematocrit, slower RBC velocity and larger blood viscosity, which can lead to the vaso-occlusive crisis and the pain of patients with sickle cell disease. Conclusions This study helps us to understand the blood flow properties of capillary networks of patients with sickle cell disease, and may help us to prevent the vaso-occlusive crisis. To improve our study, we can use capillary networks from the diseased part of sickle cell patients instead. Support or Funding Information This research is supported by Shenzhen Science and Technology Innovation Institution (China) Grant JCYJ20160427170536358 (Y Huo). This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
- W3173428488 created "2021-07-05" @default.
- W3173428488 creator A5023291436 @default.
- W3173428488 creator A5088889008 @default.
- W3173428488 date "2019-04-01" @default.
- W3173428488 modified "2023-10-18" @default.
- W3173428488 title "Hemodynamics of Capillary Networks in Sickle Cell Disease" @default.
- W3173428488 doi "https://doi.org/10.1096/fasebj.2019.33.1_supplement.521.1" @default.
- W3173428488 hasPublicationYear "2019" @default.
- W3173428488 type Work @default.
- W3173428488 sameAs 3173428488 @default.
- W3173428488 citedByCount "0" @default.
- W3173428488 crossrefType "journal-article" @default.
- W3173428488 hasAuthorship W3173428488A5023291436 @default.
- W3173428488 hasAuthorship W3173428488A5088889008 @default.
- W3173428488 hasConcept C126322002 @default.
- W3173428488 hasConcept C158846371 @default.
- W3173428488 hasConcept C159985019 @default.
- W3173428488 hasConcept C164705383 @default.
- W3173428488 hasConcept C178853913 @default.
- W3173428488 hasConcept C192562407 @default.
- W3173428488 hasConcept C196806460 @default.
- W3173428488 hasConcept C2779134260 @default.
- W3173428488 hasConcept C2780959883 @default.
- W3173428488 hasConcept C2994203641 @default.
- W3173428488 hasConcept C71924100 @default.
- W3173428488 hasConceptScore W3173428488C126322002 @default.
- W3173428488 hasConceptScore W3173428488C158846371 @default.
- W3173428488 hasConceptScore W3173428488C159985019 @default.
- W3173428488 hasConceptScore W3173428488C164705383 @default.
- W3173428488 hasConceptScore W3173428488C178853913 @default.
- W3173428488 hasConceptScore W3173428488C192562407 @default.
- W3173428488 hasConceptScore W3173428488C196806460 @default.
- W3173428488 hasConceptScore W3173428488C2779134260 @default.
- W3173428488 hasConceptScore W3173428488C2780959883 @default.
- W3173428488 hasConceptScore W3173428488C2994203641 @default.
- W3173428488 hasConceptScore W3173428488C71924100 @default.
- W3173428488 hasIssue "S1" @default.
- W3173428488 hasLocation W31734284881 @default.
- W3173428488 hasOpenAccess W3173428488 @default.
- W3173428488 hasPrimaryLocation W31734284881 @default.
- W3173428488 hasRelatedWork W1580159 @default.
- W3173428488 hasRelatedWork W1879471427 @default.
- W3173428488 hasRelatedWork W1934807271 @default.
- W3173428488 hasRelatedWork W1976605829 @default.
- W3173428488 hasRelatedWork W2011117943 @default.
- W3173428488 hasRelatedWork W2502802419 @default.
- W3173428488 hasRelatedWork W2970702908 @default.
- W3173428488 hasRelatedWork W3176146242 @default.
- W3173428488 hasRelatedWork W4225985649 @default.
- W3173428488 hasRelatedWork W84206 @default.
- W3173428488 hasVolume "33" @default.
- W3173428488 isParatext "false" @default.
- W3173428488 isRetracted "false" @default.
- W3173428488 magId "3173428488" @default.
- W3173428488 workType "article" @default.