Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173540322> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W3173540322 abstract "Objective : To investigate whether micro ribonucleic acid (miR)-103 affects pancreatic cancer (PaCa) cells via PTEN-activated PI3K/Akt signaling pathway. Methods : Differences in miR-103 expression in 35 pairs of PaCa tissues and cell lines (SW1990 and PATU8988S) were detected by RT-qPCR. miR-103 inhibitor was transfected into PaCa PATU8988S cell followed by analysis of proliferation and apoptosis of PaCa cells by MTT assay and flow cytometry, respectively. Results : MiR-103 exhibited a significantly high expression in PaCa tissues and cell lines ( p < 0.05). Besides, the exogenous inhibition of miR-103 expression in PATU8988S cells significantly inhibited cell proliferation and migration but increased apoptosis activity ( p < 0.05). According to the prediction of TargetScan biological database, miR-103 could bind PTEN 3′ untranslated region (3′UTR) and miR-103 was confirmed to suppress PTEN expression in a targeted way ( p <0.05). Furthermore, down-regulation of PTEN activated PI3K/Akt signaling to affect the proliferation and apoptosis of PaCa cells ( p < 0.05 or p <0.01). Conclusion : MiR-103 displays a significantly increased expression in PaCa cells and targets PTEN to activate PI3K/Akt signaling pathway, thus promoting malignant phenotype formation." @default.
- W3173540322 created "2021-07-05" @default.
- W3173540322 creator A5009920115 @default.
- W3173540322 creator A5026071529 @default.
- W3173540322 creator A5032080056 @default.
- W3173540322 creator A5038533816 @default.
- W3173540322 creator A5081854448 @default.
- W3173540322 creator A5089610091 @default.
- W3173540322 date "2021-04-01" @default.
- W3173540322 modified "2023-09-26" @default.
- W3173540322 title "Effects of microRNA-103 on the Proliferation and Apoptosis of Pancreatic Cancer Cells via Targeting Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) and Activating Phosphoinositide 3-Kinase/A Serine/Threonine Kinase (PI3K/Akt) Signaling Pathway" @default.
- W3173540322 doi "https://doi.org/10.1166/jbt.2021.2583" @default.
- W3173540322 hasPublicationYear "2021" @default.
- W3173540322 type Work @default.
- W3173540322 sameAs 3173540322 @default.
- W3173540322 citedByCount "0" @default.
- W3173540322 crossrefType "journal-article" @default.
- W3173540322 hasAuthorship W3173540322A5009920115 @default.
- W3173540322 hasAuthorship W3173540322A5026071529 @default.
- W3173540322 hasAuthorship W3173540322A5032080056 @default.
- W3173540322 hasAuthorship W3173540322A5038533816 @default.
- W3173540322 hasAuthorship W3173540322A5081854448 @default.
- W3173540322 hasAuthorship W3173540322A5089610091 @default.
- W3173540322 hasConcept C104317684 @default.
- W3173540322 hasConcept C145059251 @default.
- W3173540322 hasConcept C153911025 @default.
- W3173540322 hasConcept C185592680 @default.
- W3173540322 hasConcept C190283241 @default.
- W3173540322 hasConcept C2777609662 @default.
- W3173540322 hasConcept C2779549131 @default.
- W3173540322 hasConcept C502942594 @default.
- W3173540322 hasConcept C55493867 @default.
- W3173540322 hasConcept C62112901 @default.
- W3173540322 hasConcept C62478195 @default.
- W3173540322 hasConcept C75217442 @default.
- W3173540322 hasConcept C86554907 @default.
- W3173540322 hasConcept C86803240 @default.
- W3173540322 hasConcept C95444343 @default.
- W3173540322 hasConceptScore W3173540322C104317684 @default.
- W3173540322 hasConceptScore W3173540322C145059251 @default.
- W3173540322 hasConceptScore W3173540322C153911025 @default.
- W3173540322 hasConceptScore W3173540322C185592680 @default.
- W3173540322 hasConceptScore W3173540322C190283241 @default.
- W3173540322 hasConceptScore W3173540322C2777609662 @default.
- W3173540322 hasConceptScore W3173540322C2779549131 @default.
- W3173540322 hasConceptScore W3173540322C502942594 @default.
- W3173540322 hasConceptScore W3173540322C55493867 @default.
- W3173540322 hasConceptScore W3173540322C62112901 @default.
- W3173540322 hasConceptScore W3173540322C62478195 @default.
- W3173540322 hasConceptScore W3173540322C75217442 @default.
- W3173540322 hasConceptScore W3173540322C86554907 @default.
- W3173540322 hasConceptScore W3173540322C86803240 @default.
- W3173540322 hasConceptScore W3173540322C95444343 @default.
- W3173540322 hasLocation W31735403221 @default.
- W3173540322 hasOpenAccess W3173540322 @default.
- W3173540322 hasPrimaryLocation W31735403221 @default.
- W3173540322 hasRelatedWork W17382811 @default.
- W3173540322 hasRelatedWork W24485795 @default.
- W3173540322 hasRelatedWork W26362766 @default.
- W3173540322 hasRelatedWork W27528219 @default.
- W3173540322 hasRelatedWork W29321681 @default.
- W3173540322 hasRelatedWork W34869232 @default.
- W3173540322 hasRelatedWork W38481310 @default.
- W3173540322 hasRelatedWork W3962595 @default.
- W3173540322 hasRelatedWork W5521651 @default.
- W3173540322 hasRelatedWork W1039363 @default.
- W3173540322 isParatext "false" @default.
- W3173540322 isRetracted "false" @default.
- W3173540322 magId "3173540322" @default.
- W3173540322 workType "article" @default.