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- W3173547620 abstract "Resistance to CD19-directed immunotherapies in lymphoblastic leukemia has been attributed, among other factors, to several aberrant CD19 pre-mRNA splicing events, including recently reported excision of a cryptic intron embedded within CD19 exon 2. While exitrons are known to exist in hundreds of human transcripts, we discovered, using reporter assays and direct long-read RNA sequencing (dRNA-seq), that the CD19 exitron is an artifact of reverse transcription. Extending our analysis to publicly available datasets, we identified dozens of questionable exitrons, dubbed falsitrons, that appear only in cDNA-seq, but never in dRNA-seq. Our results highlight the importance of dRNA-seq for transcript isoform validation." @default.
- W3173547620 created "2021-07-05" @default.
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- W3173547620 date "2021-06-28" @default.
- W3173547620 modified "2023-10-17" @default.
- W3173547620 title "Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts" @default.
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- W3173547620 doi "https://doi.org/10.1186/s13059-021-02411-1" @default.
- W3173547620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8240250" @default.
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