Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173619749> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3173619749 abstract "Abstract Background A substantial proportion of rheumatoid arthritis (RA) patients discontinues treatment with tumour necrosis factor inhibitors (TNFi) due to inefficacy or intolerance. After the failure of treatment with a TNFi, treatment can be switched to another TNFi or a bDMARD with a different mode of action (non-TNFi). Measurement of serum drug concentrations and/or anti-drug antibodies (therapeutic drug monitoring (TDM)) may help to inform the choice for the next step. However, the clinical utility of TDM to guide switching has not been investigated in a randomised test-treatment study. Methods ADDORA-switch is a 24-week, multi-centre, triple-blinded, superiority test-treatment randomised controlled trial. A total of 84 RA patients failing adalimumab treatment (treatment failure defined as DAS28-CRP > 2.9) will be randomised in a 1:1 ratio to a switching strategy to either TNFi or non-TNFi based on adalimumab serum trough level (intervention group) or random allocation (control group). The primary outcome is the between-group difference in mean time-weighted DAS28 over 24 weeks. Discussion The trial design differs in many aspects from previously published and ongoing TDM studies and is considered the first blinded test-treatment trial using TDM in RA. Several choices in the design of this trial are described, and overarching principles regarding test-treatment trials and clinical utility of TDM are discussed in further detail. Trial registration Dutch Trial Register NL8210 . Registered on 3 December 2019 (CMO NL69841.091.19)." @default.
- W3173619749 created "2021-07-05" @default.
- W3173619749 creator A5012009272 @default.
- W3173619749 creator A5014051345 @default.
- W3173619749 creator A5029733252 @default.
- W3173619749 creator A5030365370 @default.
- W3173619749 creator A5034647146 @default.
- W3173619749 creator A5034989426 @default.
- W3173619749 creator A5044831604 @default.
- W3173619749 creator A5050087953 @default.
- W3173619749 creator A5059395956 @default.
- W3173619749 creator A5067384016 @default.
- W3173619749 date "2021-06-19" @default.
- W3173619749 modified "2023-10-17" @default.
- W3173619749 title "Using adalimumab serum concentration to choose a subsequent biological DMARD in rheumatoid arthritis patients failing adalimumab treatment (ADDORA-switch): study protocol for a fully blinded randomised superiority test-treatment trial" @default.
- W3173619749 cites W1996437423 @default.
- W3173619749 cites W2033890227 @default.
- W3173619749 cites W2096200590 @default.
- W3173619749 cites W2097735143 @default.
- W3173619749 cites W2105226906 @default.
- W3173619749 cites W2108519284 @default.
- W3173619749 cites W2117244591 @default.
- W3173619749 cites W2119046820 @default.
- W3173619749 cites W2120393706 @default.
- W3173619749 cites W2123170396 @default.
- W3173619749 cites W2141947901 @default.
- W3173619749 cites W2141953337 @default.
- W3173619749 cites W2149065814 @default.
- W3173619749 cites W2150944237 @default.
- W3173619749 cites W2155202277 @default.
- W3173619749 cites W2169713004 @default.
- W3173619749 cites W2204687884 @default.
- W3173619749 cites W2217616236 @default.
- W3173619749 cites W2272291172 @default.
- W3173619749 cites W2287689759 @default.
- W3173619749 cites W2396915667 @default.
- W3173619749 cites W2549844032 @default.
- W3173619749 cites W2589807218 @default.
- W3173619749 cites W2625351233 @default.
- W3173619749 cites W2729915389 @default.
- W3173619749 cites W2941618472 @default.
- W3173619749 cites W3008855491 @default.
- W3173619749 cites W3017091042 @default.
- W3173619749 cites W626011147 @default.
- W3173619749 doi "https://doi.org/10.1186/s13063-021-05358-7" @default.
- W3173619749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8214249" @default.
- W3173619749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34147123" @default.
- W3173619749 hasPublicationYear "2021" @default.
- W3173619749 type Work @default.
- W3173619749 sameAs 3173619749 @default.
- W3173619749 citedByCount "0" @default.
- W3173619749 crossrefType "journal-article" @default.
- W3173619749 hasAuthorship W3173619749A5012009272 @default.
- W3173619749 hasAuthorship W3173619749A5014051345 @default.
- W3173619749 hasAuthorship W3173619749A5029733252 @default.
- W3173619749 hasAuthorship W3173619749A5030365370 @default.
- W3173619749 hasAuthorship W3173619749A5034647146 @default.
- W3173619749 hasAuthorship W3173619749A5034989426 @default.
- W3173619749 hasAuthorship W3173619749A5044831604 @default.
- W3173619749 hasAuthorship W3173619749A5050087953 @default.
- W3173619749 hasAuthorship W3173619749A5059395956 @default.
- W3173619749 hasAuthorship W3173619749A5067384016 @default.
- W3173619749 hasBestOaLocation W31736197491 @default.
- W3173619749 hasConcept C126322002 @default.
- W3173619749 hasConcept C168563851 @default.
- W3173619749 hasConcept C1862650 @default.
- W3173619749 hasConcept C2777575956 @default.
- W3173619749 hasConcept C2780132546 @default.
- W3173619749 hasConcept C535046627 @default.
- W3173619749 hasConcept C71924100 @default.
- W3173619749 hasConceptScore W3173619749C126322002 @default.
- W3173619749 hasConceptScore W3173619749C168563851 @default.
- W3173619749 hasConceptScore W3173619749C1862650 @default.
- W3173619749 hasConceptScore W3173619749C2777575956 @default.
- W3173619749 hasConceptScore W3173619749C2780132546 @default.
- W3173619749 hasConceptScore W3173619749C535046627 @default.
- W3173619749 hasConceptScore W3173619749C71924100 @default.
- W3173619749 hasFunder F4320321007 @default.
- W3173619749 hasIssue "1" @default.
- W3173619749 hasLocation W31736197491 @default.
- W3173619749 hasLocation W31736197492 @default.
- W3173619749 hasOpenAccess W3173619749 @default.
- W3173619749 hasPrimaryLocation W31736197491 @default.
- W3173619749 hasRelatedWork W1969918039 @default.
- W3173619749 hasRelatedWork W2156283049 @default.
- W3173619749 hasRelatedWork W2316954211 @default.
- W3173619749 hasRelatedWork W2327246029 @default.
- W3173619749 hasRelatedWork W2352867790 @default.
- W3173619749 hasRelatedWork W2987008883 @default.
- W3173619749 hasRelatedWork W3142209233 @default.
- W3173619749 hasRelatedWork W4245782456 @default.
- W3173619749 hasRelatedWork W4253441873 @default.
- W3173619749 hasRelatedWork W875545710 @default.
- W3173619749 hasVolume "22" @default.
- W3173619749 isParatext "false" @default.
- W3173619749 isRetracted "false" @default.
- W3173619749 magId "3173619749" @default.
- W3173619749 workType "article" @default.