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- W3173619885 abstract "Significance Metabolites mediate the establishment and persistence of most interkingdom symbioses. Still, to pinpoint the metabolites each partner displays upon interaction remains the biggest challenge in studying multiorganismal assemblages. Addressing this challenge, we developed a correlative imaging workflow to connect the in situ production of metabolites with the organ-scale and cellular three-dimensional distributions of mutualistic and pathogenic (micro)organisms in the same host animal. Combining mass spectrometry imaging and micro-computed X-ray tomography provided a culture-independent approach, which is essential to include the full spectrum of naturally occurring interactions. To introduce the potential of combining high-resolution tomography with metabolite imaging, we resolved the metabolic interactions between an invertebrate host, its symbiotic bacteria, and tissue parasites at unprecedented detail for model and nonmodel symbioses." @default.
- W3173619885 created "2021-07-05" @default.
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- W3173619885 date "2021-06-28" @default.
- W3173619885 modified "2023-10-03" @default.
- W3173619885 title "Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography" @default.
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- W3173619885 doi "https://doi.org/10.1073/pnas.2023773118" @default.
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