Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173642802> ?p ?o ?g. }
- W3173642802 abstract "Glucagon is produced and released from the pancreatic alpha-cell to regulate glucose levels during periods of fasting. The main target for glucagon action is the liver, where it activates gluconeogenesis and glycogen breakdown; however, glucagon is postulated to have other roles within the body.We sought to identify the circulating metabolites that would serve as markers of glucagon action in humans.In this study (NCT03139305), we performed a continuous 72-hour glucagon infusion in healthy individuals with overweight/obesity. Participants were randomized to receive glucagon 12.5 ng/kg/min (GCG 12.5), glucagon 25 ng/kg/min (GCG 25), or a placebo control. A comprehensive metabolomics analysis was then performed from plasma isolated at several time points during the infusion to identify markers of glucagon activity.Glucagon (GCG 12.5 and GCG 25) resulted in significant changes in the plasma metabolome as soon as 4 hours following infusion. Pathways involved in amino acid metabolism were among the most affected. Rapid and sustained reduction of a broad panel of amino acids was observed. Additionally, time-dependent changes in free fatty acids and diacylglycerol and triglyceride species were observed.These results define a distinct signature of glucagon action that is broader than the known changes in glucose levels. In particular, the robust changes in amino acid levels may prove useful to monitor changes induced by glucagon in the context of additional glucagon-like peptide-1 or gastric inhibitory polypeptide treatment, as these agents also elicit changes in glucose levels." @default.
- W3173642802 created "2021-07-05" @default.
- W3173642802 creator A5000014440 @default.
- W3173642802 creator A5021201805 @default.
- W3173642802 creator A5029478203 @default.
- W3173642802 creator A5033584402 @default.
- W3173642802 creator A5049219012 @default.
- W3173642802 creator A5056681317 @default.
- W3173642802 creator A5057946215 @default.
- W3173642802 creator A5058441976 @default.
- W3173642802 creator A5067986711 @default.
- W3173642802 creator A5071015774 @default.
- W3173642802 creator A5074209018 @default.
- W3173642802 creator A5077210256 @default.
- W3173642802 creator A5079615377 @default.
- W3173642802 date "2021-06-25" @default.
- W3173642802 modified "2023-10-16" @default.
- W3173642802 title "A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity" @default.
- W3173642802 cites W1020165511 @default.
- W3173642802 cites W1573089314 @default.
- W3173642802 cites W1758030804 @default.
- W3173642802 cites W1986673931 @default.
- W3173642802 cites W1988195734 @default.
- W3173642802 cites W1998200369 @default.
- W3173642802 cites W2013438463 @default.
- W3173642802 cites W2019010829 @default.
- W3173642802 cites W2028972425 @default.
- W3173642802 cites W2031689292 @default.
- W3173642802 cites W2045962469 @default.
- W3173642802 cites W2053015140 @default.
- W3173642802 cites W2074547710 @default.
- W3173642802 cites W2085330452 @default.
- W3173642802 cites W2090607393 @default.
- W3173642802 cites W2115939390 @default.
- W3173642802 cites W2133740866 @default.
- W3173642802 cites W2145833822 @default.
- W3173642802 cites W2146512944 @default.
- W3173642802 cites W2148623180 @default.
- W3173642802 cites W2154497567 @default.
- W3173642802 cites W2159482845 @default.
- W3173642802 cites W2164798436 @default.
- W3173642802 cites W2171474087 @default.
- W3173642802 cites W2207556001 @default.
- W3173642802 cites W2244700942 @default.
- W3173642802 cites W2306265054 @default.
- W3173642802 cites W2464238397 @default.
- W3173642802 cites W2482901886 @default.
- W3173642802 cites W2594275078 @default.
- W3173642802 cites W2600127085 @default.
- W3173642802 cites W2762892866 @default.
- W3173642802 cites W2808958607 @default.
- W3173642802 cites W2809586755 @default.
- W3173642802 cites W2886911834 @default.
- W3173642802 cites W2940783197 @default.
- W3173642802 cites W2946612907 @default.
- W3173642802 cites W3085056884 @default.
- W3173642802 cites W3165203237 @default.
- W3173642802 cites W4294216483 @default.
- W3173642802 doi "https://doi.org/10.1210/jendso/bvab118" @default.
- W3173642802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8317630" @default.
- W3173642802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34337278" @default.
- W3173642802 hasPublicationYear "2021" @default.
- W3173642802 type Work @default.
- W3173642802 sameAs 3173642802 @default.
- W3173642802 citedByCount "9" @default.
- W3173642802 countsByYear W31736428022021 @default.
- W3173642802 countsByYear W31736428022022 @default.
- W3173642802 countsByYear W31736428022023 @default.
- W3173642802 crossrefType "journal-article" @default.
- W3173642802 hasAuthorship W3173642802A5000014440 @default.
- W3173642802 hasAuthorship W3173642802A5021201805 @default.
- W3173642802 hasAuthorship W3173642802A5029478203 @default.
- W3173642802 hasAuthorship W3173642802A5033584402 @default.
- W3173642802 hasAuthorship W3173642802A5049219012 @default.
- W3173642802 hasAuthorship W3173642802A5056681317 @default.
- W3173642802 hasAuthorship W3173642802A5057946215 @default.
- W3173642802 hasAuthorship W3173642802A5058441976 @default.
- W3173642802 hasAuthorship W3173642802A5067986711 @default.
- W3173642802 hasAuthorship W3173642802A5071015774 @default.
- W3173642802 hasAuthorship W3173642802A5074209018 @default.
- W3173642802 hasAuthorship W3173642802A5077210256 @default.
- W3173642802 hasAuthorship W3173642802A5079615377 @default.
- W3173642802 hasBestOaLocation W31736428021 @default.
- W3173642802 hasConcept C126322002 @default.
- W3173642802 hasConcept C134018914 @default.
- W3173642802 hasConcept C135870905 @default.
- W3173642802 hasConcept C141359234 @default.
- W3173642802 hasConcept C151730666 @default.
- W3173642802 hasConcept C185592680 @default.
- W3173642802 hasConcept C20904676 @default.
- W3173642802 hasConcept C2776398474 @default.
- W3173642802 hasConcept C2777180221 @default.
- W3173642802 hasConcept C2777477808 @default.
- W3173642802 hasConcept C2777499176 @default.
- W3173642802 hasConcept C2778563252 @default.
- W3173642802 hasConcept C2779306644 @default.
- W3173642802 hasConcept C2779343474 @default.
- W3173642802 hasConcept C555293320 @default.
- W3173642802 hasConcept C62231903 @default.
- W3173642802 hasConcept C71924100 @default.