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- W3173644655 endingPage "945" @default.
- W3173644655 startingPage "945" @default.
- W3173644655 abstract "Messenger RNA (mRNA) is being extensively used in gene therapy and vaccination due to its safety over DNA, in the following ways: its lack of integration risk, cytoplasmic expression, and transient expression compatible with fine regulations. However, clinical applications of mRNA are limited by its fast degradation by nucleases, and the activation of detrimental immune responses. Advances in mRNA applications, with the recent approval of COVID-19 vaccines, were fueled by optimization of the mRNA sequence and the development of mRNA delivery systems. Although delivery systems and mRNA sequence optimization have been abundantly reviewed, understanding of the intracellular processing of mRNA is mandatory to improve its applications. We will focus on lipid nanoparticles (LNPs) as they are the most advanced nanocarriers for the delivery of mRNA. Here, we will review how mRNA therapeutic potency can be affected by its interactions with cellular proteins and intracellular distribution." @default.
- W3173644655 created "2021-07-05" @default.
- W3173644655 creator A5014043297 @default.
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- W3173644655 creator A5052657747 @default.
- W3173644655 creator A5069709613 @default.
- W3173644655 creator A5084845535 @default.
- W3173644655 date "2021-06-24" @default.
- W3173644655 modified "2023-09-25" @default.
- W3173644655 title "Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles" @default.
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