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- W3173649809 endingPage "120851" @default.
- W3173649809 startingPage "120851" @default.
- W3173649809 abstract "Over the past two decades, RNA interference has become an extensively studied mechanism to silence gene and treat diseases including cancer. siRNA appears as a promising strategy that could avoid some side effects related to traditional chemotherapy. Considering the weak stability of naked siRNA in blood, vectors like cationic liposomes or Lipid Nanoparticles (LNPs) are widely used to carry and protect siRNA until it reaches the tumor targeted. Despite extensive research, only three RNAi drugs are currently approved by the Food and Drug Administration, including only one LNP formulation of siRNA to treat hereditary ATTR amyloidosis. This shows the difficulty of lipoplexes clinical translation, in particular in cancer therapy. To overcome the lipoplexes limitations, searches are made on innovative lipoplexes formulations with enhanced siRNA efficacy. The present review is focusing on the recent use of pH-sensitive lipids, peptides and cell-penetrating peptides or polymers. The incorporation of some of these components in the lipoplex formulation induces a fusogenic property or an enhanced endosomal escape, an enhanced cellular uptake, an enhanced tumor targeting, an improved stability in the blood stream …These innovations appear critical to obtain an efficient siRNA accumulation in tumor cells with effective antitumor effect considering the complex tumor environment." @default.
- W3173649809 created "2021-07-05" @default.
- W3173649809 creator A5062362381 @default.
- W3173649809 creator A5076287532 @default.
- W3173649809 creator A5084708096 @default.
- W3173649809 creator A5090765919 @default.
- W3173649809 date "2021-08-01" @default.
- W3173649809 modified "2023-09-25" @default.
- W3173649809 title "Innovative lipoplexes formulations with enhanced siRNA efficacy for cancer treatment: Where are we now?" @default.
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