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- W3173661342 abstract "We tested the hypothesis that impaired fasting blood glucose (IFG) exacerbates vascular endothelial dysfunction with aging, and that this effect is smaller or prevented by habitual exercise. Brachial artery flow-mediated (endothelium-dependent) dilation (FMD) was lower (5.14±0.38 vs. 8.06±0.35 %Δ, P<0.001) in older adults with normal fasting blood glucose (NFG, ≤99 mg/dl, 62±1 yrs, n=37, 31M/6F) vs. young NFG controls (24±1, n=29, 26/3). FMD was further impaired (3.62±0.38 %Δ, P<0.01 vs. older NFG) in otherwise healthy older adults with IFG (100–125 mg/dl, 64±1, n=31, 26/5). Older adults with NFG who regularly (≥3d/w) performed moderate to vigorous aerobic exercise (62±1, n=23, 21/2) had largely preserved FMD (6.38±0.35 %Δ, P<0.05 vs. older NFG). Most importantly, FMD also was well preserved (7.02±0.65 %Δ) in older exercising adults with IFG (65±1, n=17, 13/4). These overall group differences remained significant (P<0.05) after controlling for endothelium-independent dilation and clinical characteristics. In the pooled sample (n=137), FMD was inversely related to FG (r=−0.32, P<0.001), plasma insulin (r=−0.23, P<0.05) and an index of insulin resistance, HOMA-IR (r=−0.28, P<0.01). IFG, a prediabetic state, exacerbates age-associated vascular endothelial dysfunction. This adverse effect is prevented by regular aerobic exercise. NIH AG013038, AG000279, AG031617, AG033994, AG027910, RR025780" @default.
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- W3173661342 date "2012-04-01" @default.
- W3173661342 modified "2023-09-23" @default.
- W3173661342 title "Impaired fasting blood glucose‐related exacerbation of age‐associated vascular endothelial dysfunction: protective effect of regular aerobic exercise" @default.
- W3173661342 doi "https://doi.org/10.1096/fasebj.26.1_supplement.865.2" @default.
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