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- W3173676343 abstract "Abstract Cell identity is maintained by activation of cell-specific gene programs, regulated by epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4)-folded regions in cells were reported to be associated with either increased or decreased transcriptional activity. By G4-ChIP-seq/RNA-seq analysis on liposarcoma cells we confirmed that G4s in promoters are invariably associated with high transcription levels in open chromatin. Comparing G4 presence, location and transcript levels in liposarcoma cells to available data on keratinocytes, we showed that the same promoter sequences of the same genes in the two cell lines had different G4-folding state: high transcript levels consistently associated with G4-folding. Transcription factors AP-1 and SP1, whose binding sites were the most significantly represented in G4-folded sequences, coimmunoprecipitated with their G4-folded promoters. Thus, G4s and their associated transcription factors cooperate to determine cell-specific transcriptional programs, making G4s to strongly emerge as new epigenetic regulators of the transcription machinery." @default.
- W3173676343 created "2021-07-05" @default.
- W3173676343 creator A5048348507 @default.
- W3173676343 creator A5050967332 @default.
- W3173676343 creator A5058141873 @default.
- W3173676343 creator A5064443367 @default.
- W3173676343 creator A5069115725 @default.
- W3173676343 creator A5080558745 @default.
- W3173676343 creator A5084721168 @default.
- W3173676343 date "2021-06-23" @default.
- W3173676343 modified "2023-10-01" @default.
- W3173676343 title "Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome" @default.
- W3173676343 cites W1450574606 @default.
- W3173676343 cites W1531821806 @default.
- W3173676343 cites W1541937812 @default.
- W3173676343 cites W1789563956 @default.
- W3173676343 cites W1810920534 @default.
- W3173676343 cites W1960874025 @default.
- W3173676343 cites W1967987158 @default.
- W3173676343 cites W1969528530 @default.
- W3173676343 cites W1990635146 @default.
- W3173676343 cites W1991754576 @default.
- W3173676343 cites W2010333332 @default.
- W3173676343 cites W2016334273 @default.
- W3173676343 cites W2033332310 @default.
- W3173676343 cites W2042374693 @default.
- W3173676343 cites W2050913592 @default.
- W3173676343 cites W2053849641 @default.
- W3173676343 cites W2056201880 @default.
- W3173676343 cites W2057489128 @default.
- W3173676343 cites W2059126678 @default.
- W3173676343 cites W2059306569 @default.
- W3173676343 cites W2062404433 @default.
- W3173676343 cites W2066578663 @default.
- W3173676343 cites W2066664002 @default.
- W3173676343 cites W2073877214 @default.
- W3173676343 cites W2080193994 @default.
- W3173676343 cites W2082739830 @default.
- W3173676343 cites W2089310643 @default.
- W3173676343 cites W2090894089 @default.
- W3173676343 cites W2092424765 @default.
- W3173676343 cites W2098883600 @default.
- W3173676343 cites W2099482139 @default.
- W3173676343 cites W2100966371 @default.
- W3173676343 cites W2102619694 @default.
- W3173676343 cites W2108234281 @default.
- W3173676343 cites W2112741367 @default.
- W3173676343 cites W2117692326 @default.
- W3173676343 cites W2129288285 @default.
- W3173676343 cites W2130245511 @default.
- W3173676343 cites W2147643191 @default.
- W3173676343 cites W2149627698 @default.
- W3173676343 cites W2153879694 @default.
- W3173676343 cites W2155773930 @default.
- W3173676343 cites W2161527747 @default.
- W3173676343 cites W2161579926 @default.
- W3173676343 cites W2165604073 @default.
- W3173676343 cites W2169745877 @default.
- W3173676343 cites W2171808845 @default.
- W3173676343 cites W2201671538 @default.
- W3173676343 cites W2235657766 @default.
- W3173676343 cites W2251344425 @default.
- W3173676343 cites W2257749782 @default.
- W3173676343 cites W2290989326 @default.
- W3173676343 cites W2385823688 @default.
- W3173676343 cites W2426177481 @default.
- W3173676343 cites W2462053388 @default.
- W3173676343 cites W2474238973 @default.
- W3173676343 cites W2510312826 @default.
- W3173676343 cites W2520749639 @default.
- W3173676343 cites W2529059585 @default.
- W3173676343 cites W2535847981 @default.
- W3173676343 cites W2539691326 @default.
- W3173676343 cites W2547929719 @default.
- W3173676343 cites W2610903912 @default.
- W3173676343 cites W2616255601 @default.
- W3173676343 cites W2750416916 @default.
- W3173676343 cites W2752071614 @default.
- W3173676343 cites W2757691983 @default.
- W3173676343 cites W2778879300 @default.
- W3173676343 cites W2780677469 @default.
- W3173676343 cites W2782869690 @default.
- W3173676343 cites W2890033993 @default.
- W3173676343 cites W2893849467 @default.
- W3173676343 cites W2912193009 @default.
- W3173676343 cites W2923522997 @default.
- W3173676343 cites W2949071111 @default.
- W3173676343 cites W2950221693 @default.
- W3173676343 cites W2951171673 @default.
- W3173676343 cites W2964115740 @default.
- W3173676343 cites W2965468488 @default.
- W3173676343 cites W2969636872 @default.
- W3173676343 cites W2974694133 @default.
- W3173676343 cites W2976449702 @default.
- W3173676343 cites W2980848506 @default.
- W3173676343 cites W3005037272 @default.
- W3173676343 cites W3021346375 @default.
- W3173676343 cites W3047068833 @default.
- W3173676343 cites W3047264471 @default.
- W3173676343 cites W3119268364 @default.