FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173724664> ?p ?o ?g. }

• W3173724664 abstract "Background: Reliable insulin delivery is critical in the management of type 1 diabetes. Limitations of insulin pump therapy (IPT) are the maximum cannula life of three days, and a reported failure rate of 15-25% prior to this, which may impact glycemia and quality of life. Objective: We aimed to determine the feasibility of a prototype cannula for an extended wear infusion set. Materials and Methods: CapBio’s SteadiFlow technology (Capillary Biomedical, Irvine, CA, USA) consists of a cannula with a soft outer polymer reinforced by an internal metal coil to prevent kinking and three additional side ports to reduce the risk of cannula blockages. Adults with type 1 diabetes using IPT participated in a study with three study periods. For each period a new infusion set was inserted for an intended wear of 7 days. During Period 1 saline was infused via the investigational set through an additional insulin pump. During Periods 2 and 3 insulin lispro was delivered via the investigational set connected to the participant’s own insulin pump. Results are expressed as mean (SD). Results: Twenty participants (Medtronic 640G [n=11]; 670G [n=3]; Tandem t-slim X2 [n=6]) with type 1 diabetes (age 44Y [14]; HbA1c 7.3% [0.6]/56mmol/mol [6]; female 50%) were studied. The 7-day survival rates of the prototype cannula set were 19/20 (95%) for period one and 36/41(88%) for periods two and three combined. No serious adverse events were reported. Mild infusion site reactions occurred in 7 participants. Hyperglycemia was reported as an adverse event in 7 participants resulting in premature cannula removal in 4 cases (occurring, respectively, on Days 1, 2, 5, and 6 during Weeks 2 or 3). Infusion site infection caused the 5th premature removal (on Day 3). Post-removal, no kinked cannulas were observed. Conclusions: These study results confirm the feasibility of the extended-life investigational cannula. Larger, randomised studies are required to confirm these preliminary observations. Disclosure D. N. O’neal: Advisory Panel; Self; Abbott Diabetes, Medtronic, Sanofi, Research Support; Self; Dexcom, Inc., GlySens Incorporated, Medtronic, Pacific Diabetes Technologies. N. Venkatesh: None. K. Brown: None. E. I. Ekinci: None. S. Fourlanos: Advisory Panel; Self; Pfizer Foundation, Speaker’s Bureau; Self; AstraZeneca, Eli Lilly and Company. J. R. Kastner: None. R. Macisaac: Advisory Panel; Self; AstraZeneca, Bayer Healthcare Pharmaceuticals Inc., Novo Nordisk, Servier Laboratories, Speaker’s Bureau; Self; Boehringer Ingelheim International GmbH, Novo Nordisk. D. B. Muchmore: Consultant; Self; Capillary Biomedical, Inc., Diasome Pharmaceuticals, Inc., Zucara Therapeutics Inc., Stock/Shareholder; Self; Capillary Biomedical, Inc., Diasome Pharmaceuticals, Inc." @default.
• W3173724664 created "2021-07-05" @default.
• W3173724664 creator A5003469080 @default.
• W3173724664 creator A5006069892 @default.
• W3173724664 creator A5013159981 @default.
• W3173724664 creator A5013317756 @default.
• W3173724664 creator A5036715888 @default.
• W3173724664 creator A5042470171 @default.
• W3173724664 creator A5053193359 @default.
• W3173724664 creator A5088483996 @default.
• W3173724664 date "2021-06-01" @default.
• W3173724664 modified "2023-10-11" @default.
• W3173724664 title "701-P: Feasibility of an Investigational Extended Wear Infusion Set for Insulin Pump Therapy (IPT) in People with Type 1 Diabetes Mellitus" @default.
• W3173724664 doi "https://doi.org/10.2337/db21-701-p" @default.
• W3173724664 hasPublicationYear "2021" @default.
• W3173724664 type Work @default.
• W3173724664 sameAs 3173724664 @default.
• W3173724664 citedByCount "1" @default.
• W3173724664 countsByYear W31737246642022 @default.
• W3173724664 crossrefType "journal-article" @default.
• W3173724664 hasAuthorship W3173724664A5003469080 @default.
• W3173724664 hasAuthorship W3173724664A5006069892 @default.
• W3173724664 hasAuthorship W3173724664A5013159981 @default.
• W3173724664 hasAuthorship W3173724664A5013317756 @default.
• W3173724664 hasAuthorship W3173724664A5036715888 @default.
• W3173724664 hasAuthorship W3173724664A5042470171 @default.
• W3173724664 hasAuthorship W3173724664A5053193359 @default.
• W3173724664 hasAuthorship W3173724664A5088483996 @default.
• W3173724664 hasConcept C126322002 @default.
• W3173724664 hasConcept C134018914 @default.
• W3173724664 hasConcept C141071460 @default.
• W3173724664 hasConcept C197934379 @default.
• W3173724664 hasConcept C2777180221 @default.
• W3173724664 hasConcept C2778074680 @default.
• W3173724664 hasConcept C2779306644 @default.
• W3173724664 hasConcept C2779417425 @default.
• W3173724664 hasConcept C2779794567 @default.
• W3173724664 hasConcept C2781232474 @default.
• W3173724664 hasConcept C555293320 @default.
• W3173724664 hasConcept C71924100 @default.
• W3173724664 hasConceptScore W3173724664C126322002 @default.
• W3173724664 hasConceptScore W3173724664C134018914 @default.
• W3173724664 hasConceptScore W3173724664C141071460 @default.
• W3173724664 hasConceptScore W3173724664C197934379 @default.
• W3173724664 hasConceptScore W3173724664C2777180221 @default.
• W3173724664 hasConceptScore W3173724664C2778074680 @default.
• W3173724664 hasConceptScore W3173724664C2779306644 @default.
• W3173724664 hasConceptScore W3173724664C2779417425 @default.
• W3173724664 hasConceptScore W3173724664C2779794567 @default.
• W3173724664 hasConceptScore W3173724664C2781232474 @default.
• W3173724664 hasConceptScore W3173724664C555293320 @default.
• W3173724664 hasConceptScore W3173724664C71924100 @default.
• W3173724664 hasIssue "Supplement_1" @default.
• W3173724664 hasLocation W31737246641 @default.
• W3173724664 hasOpenAccess W3173724664 @default.
• W3173724664 hasPrimaryLocation W31737246641 @default.
• W3173724664 hasRelatedWork W1980646955 @default.
• W3173724664 hasRelatedWork W1994584983 @default.
• W3173724664 hasRelatedWork W1998926154 @default.
• W3173724664 hasRelatedWork W2123666561 @default.
• W3173724664 hasRelatedWork W2132655640 @default.
• W3173724664 hasRelatedWork W2133082929 @default.
• W3173724664 hasRelatedWork W2520669174 @default.
• W3173724664 hasRelatedWork W2588769879 @default.
• W3173724664 hasRelatedWork W3173724664 @default.
• W3173724664 hasRelatedWork W4376608770 @default.
• W3173724664 hasVolume "70" @default.
• W3173724664 isParatext "false" @default.
• W3173724664 isRetracted "false" @default.
• W3173724664 magId "3173724664" @default.
• W3173724664 workType "article" @default.