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• W3173751098 endingPage "503373" @default.
• W3173751098 startingPage "503373" @default.
• W3173751098 abstract "Chromosomal aberrations (CAs) in peripheral blood lymphocytes can be used as biomarkers of cancer risk. Cytogenetic tests were conducted on 2396 healthy Hungarian individuals and cancer incidence was followed up from 1989 to 2018. Venous blood samples were obtained from the subjects and metaphases from lymphocyte cultures were prepared. We compared the CA frequencies of the various smoking (1−5; 6−10; 11−19; or 20−40 cigarettes/day) and exposure (irradiation; chemical industry; chemical research laboratory) groups. Chromatid break (p = 0.0002), total aberration (p = 0.002), and aberrant cell (p = 0.001) frequencies were higher in smokers than in non-smokers. For very heavy smokers, total CAs were significantly higher than for non-smokers (<0.001) or less intensive smokers (p = 0.003−0.0006). Intensity of smoking was a predictor of chromosomal aberrations, while duration was not. During follow-up, 177 (7.3 %) cancer cases were found. A Cox-regression model showed that subjects with cell values ≥2 CAs developed cancer more frequently (hazard ratio = 1.39; 95 % CI, 1.02–1.90). The relative risks of cancer were 1.06 (95 % CI 0.53−2.06) for light smokers and 1.74 (95 % CI 1.08−2.77) for very heavy smokers. The distributions of cancer sites showed differences between smoker and non-smoker groups: in male smokers, lung cancer, in non-smokers, prostate, and in females (both groups) breast cancer were most common. Cancer incidence correlated with chromosome aberrations; smoking was not a confounder in this relationship." @default.
• W3173751098 created "2021-07-05" @default.
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• W3173751098 date "2021-07-01" @default.
• W3173751098 modified "2023-10-16" @default.
• W3173751098 title "Smoking, chromosomal aberrations, and cancer incidence in healthy subjects" @default.
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• W3173751098 doi "https://doi.org/10.1016/j.mrgentox.2021.503373" @default.
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