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• W3173752212 abstract "West Nile virus neuroinvasive disease (WNV-NID) is challenging to diagnose. Procalcitonin (PCT) is a useful diagnostic test to identify bacterial infections. We present four cases of WNV-NID with serum PCT measurements.Daily (days 1-7) serum PCT (bioMérieux) was examined for critically ill patients with sepsis enrolled in a provincial sepsis study. Patients with identified WNV-NID are descriptively analyzed in this case series. PCT values of ≥0.5 ng/mL were suggestive of bacterial infection.Four patients with WNV-NID were identified. Those with viral infections alone had consistently low PCT values ranging from 0.09 ng/mL to 0.34 ng/mL. Those with documented bacterial co-infections had initially elevated PCT levels that decreased by more than 50% with antimicrobial therapy.These cases are the first to report serial PCT measurements in confirmed cases of WNV-NID and support a low serum PCT in WNV-NID.La maladie neuro-invasive causée par le virus du Nil occidental (MNI-VNO) est difficile à diagnostiquer. La procalcitonine (PCT) est un test diagnostique utile pour dépister les infections bactériennes. Les auteurs présentent quatre cas de MNI-VNO assortis de mesures de PCT sérique.Les chercheurs ont procédé à l’examen quotidien (jours 1 à 7) du PCT sérique (bioMérieux) chez des patients gravement malades et atteints de sepsis recrutés dans une étude provinciale du sepsis. Les patients retenus à cause d’une MNI-VNO établie font l’objet d’une analyse descriptive dans cette série de cas. Les valeurs de PCT de 0,5 ng/mL ou plus étaient évocatrices d’une infection bactérienne.Quatre patients atteints d’une MNI-VNO ont été retenus. Ceux qui n’étaient atteints que d’une infection virale obtenaient des valeurs de PCT faibles, de 0,09 ng/mL à 0,34 ng/mL. Ceux qui étaient atteints de co-infections bactériennes démontrées commençaient par obtenir des taux élevés de PCT, qui diminuaient de plus de 50 % après un traitement antimicrobien.Ces cas sont les premiers à faire état des mesures sérielles de la PCT dans des cas confirmés de MNI-VNO et à soutenir une faible PCT sérique en présence de MNI-VNO." @default.
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• W3173752212 date "2021-09-30" @default.
• W3173752212 modified "2023-09-26" @default.
• W3173752212 title "Procalcitonin measurement in West Nile virus neuroinvasive disease: A first case series" @default.
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• W3173752212 doi "https://doi.org/10.3138/jammi-2020-0046" @default.
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