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- W3173754723 abstract "Intoxication of murine macrophages (RAW 264.7) with the lethal dose of the anthrax lethal toxin (LeTx 100 ng/ml) results in profound alterations in the host cell gene expression. The role of LeTx in mediating these effects is unknown, largely due to the difficulty in identifying and assigning function to individual proteins. In this study, we have used two-dimensional polyacrylamide gel electrophoresis to analyze the protein profile of murine macrophages treated with the LeTx, and have coupled this to protein identification using MALDI-TOF mass spectrometry. Interpretation of the peptide mass fingerprint data has relied primarily on the ProFound database. Among the differentially expressed spots, glucose-6-phosphate dehydrogenase was increased in the LeTx treated macrophages. G6PD plays the role for the protection of the cells from the hyper-production of active oxygen. Our results suggest that this proteomic approach is a useful tool to study protein expression in intoxicated macrophages and will contribute to the identification of a putative substrate for LeTx." @default.
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- W3173754723 date "2006-03-01" @default.
- W3173754723 modified "2023-10-16" @default.
- W3173754723 title "Proteome profiling of murine macrophages treated with anthrax lethal toxin" @default.
- W3173754723 doi "https://doi.org/10.1096/fasebj.20.4.a65-a" @default.
- W3173754723 hasPublicationYear "2006" @default.
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