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- W3173770116 abstract "Background Cold-induced constriction of cutaneous arteries is a normal protective physiologic response that reduces heat loss. The most of studies evaluating mechanisms underlying cold-induced constriction in isolated arteries have been performed in vessels other than digital arteries. Thus, these studies may not accurately reflect the pathophysiologic mechanism(s) responsible for cold-induced constriction in digital vessels of Scleroderma/Raynaud’s patients. Objectives To determine (1) the response of non-human primate (NHP) digital/skin arteries to a cold stimulus and (2) assess the role of α1 and α2 adrenergic receptors during cooling. Methods Isolated digital (203±12 μm, n=24) and skin (163±14 μm, n=5) arteries were mounted on an arteriograph and pressurized to 100 mmHg and 60 mmHg, respectively. After determining endothelial and vascular smooth muscle integrity, we assessed the effect of cooling from 37°C to 23°C on vascular tone. We next determined the effects of α1 (phenylephrine), α2 (UK-14,303) and α1/α2 (norepinephrine) adrenergic receptor agonists on arterial tone at 37°C and 23°C. Results/Conclusions NHP digital/skin arteries constrict significantly in response to cold stress. In contrast to previously published studies in murine tail arteries, we observed an attenuation of α1 and α2-adrenergic signaling with cold exposure, suggesting that the signaling mechanisms responsible for cold-induced vasoconstriction depend on the vascular bed and/or the species studied. This research was supported by departmental start-up funds to DME." @default.
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- W3173770116 date "2006-03-01" @default.
- W3173770116 modified "2023-09-26" @default.
- W3173770116 title "Effect of cooling on α‐adrenergic signaling in non‐human primate (NHP) digital and skin arteries" @default.
- W3173770116 doi "https://doi.org/10.1096/fasebj.20.4.a272" @default.
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