Matches in SemOpenAlex for { <https://semopenalex.org/work/W317383459> ?p ?o ?g. }
- W317383459 endingPage "414" @default.
- W317383459 startingPage "409" @default.
- W317383459 abstract "Mitogen inducible gene 6 (Mig-6) is an important mediator of progesterone (P4) signaling to inhibit estrogen (E2) signaling in the uterus. Ablation of Mig-6 in the murine uterus leads to the development of endometrial hyperplasia and E2-induced endometrial cancer. To identify the molecular pathways regulated by Mig-6, we performed microarray analysis on the uterus of ovariectomized Mig-6(f/f) and PGR(cre/+)Mig-6(f/f) (Mig-6(d/d)) mice treated with vehicle or P4 for 6 h. The results revealed that 772 transcripts were significantly regulated in the Mig-6(d/d) uterus treated with vehicle as compared with Mig-6(f/f) mice. The pathway analysis showed that Mig-6 suppressed the expression of gene-related cell cycle regulation in the absence of ovarian steroid hormone. The epithelium of Mig-6(d/d) mice showed a significant increase in the number of proliferative cells compared to Mig-6(f/f) mice. This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2, the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis. To determine the role of Cited2 in the uterus, we used the mice with Cited2 that were conditionally ablated in progesterone receptor-positive cells (PGR(cre/+)Cited2(f/f); Cited2(d/d)). Ablation of Cited2 in the uterus resulted in a significant reduction in the ability of the uterus to undergo a hormonally induced decidual reaction. Identification and analysis of these responsive genes will help define the role of P4 as well as Mig-6 in regulating uterine biology." @default.
- W317383459 created "2016-06-24" @default.
- W317383459 creator A5016343667 @default.
- W317383459 creator A5024266611 @default.
- W317383459 creator A5024781173 @default.
- W317383459 creator A5041455638 @default.
- W317383459 creator A5062333532 @default.
- W317383459 creator A5087387214 @default.
- W317383459 date "2015-07-01" @default.
- W317383459 modified "2023-10-14" @default.
- W317383459 title "Mig-6 regulates endometrial genes involved in cell cycle and progesterone signaling" @default.
- W317383459 cites W1247802 @default.
- W317383459 cites W1590222977 @default.
- W317383459 cites W1885059125 @default.
- W317383459 cites W1963928942 @default.
- W317383459 cites W1967723511 @default.
- W317383459 cites W1980498769 @default.
- W317383459 cites W1985124071 @default.
- W317383459 cites W1989927010 @default.
- W317383459 cites W1998290637 @default.
- W317383459 cites W2007104335 @default.
- W317383459 cites W2007956592 @default.
- W317383459 cites W2011590093 @default.
- W317383459 cites W2020668337 @default.
- W317383459 cites W2021359436 @default.
- W317383459 cites W2029835723 @default.
- W317383459 cites W2033869679 @default.
- W317383459 cites W2038437697 @default.
- W317383459 cites W2045327531 @default.
- W317383459 cites W2051121172 @default.
- W317383459 cites W2056146352 @default.
- W317383459 cites W2056357500 @default.
- W317383459 cites W2058910623 @default.
- W317383459 cites W2059485906 @default.
- W317383459 cites W2069250127 @default.
- W317383459 cites W2082559087 @default.
- W317383459 cites W2097812262 @default.
- W317383459 cites W2103856520 @default.
- W317383459 cites W2112264507 @default.
- W317383459 cites W2116705584 @default.
- W317383459 cites W2124121505 @default.
- W317383459 cites W2131074211 @default.
- W317383459 cites W2140095844 @default.
- W317383459 cites W2148734624 @default.
- W317383459 cites W2165128924 @default.
- W317383459 cites W2188419301 @default.
- W317383459 cites W4231488642 @default.
- W317383459 doi "https://doi.org/10.1016/j.bbrc.2015.04.146" @default.
- W317383459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4461536" @default.
- W317383459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25976672" @default.
- W317383459 hasPublicationYear "2015" @default.
- W317383459 type Work @default.
- W317383459 sameAs 317383459 @default.
- W317383459 citedByCount "11" @default.
- W317383459 countsByYear W3173834592015 @default.
- W317383459 countsByYear W3173834592016 @default.
- W317383459 countsByYear W3173834592017 @default.
- W317383459 countsByYear W3173834592018 @default.
- W317383459 countsByYear W3173834592019 @default.
- W317383459 countsByYear W3173834592021 @default.
- W317383459 countsByYear W3173834592022 @default.
- W317383459 crossrefType "journal-article" @default.
- W317383459 hasAuthorship W317383459A5016343667 @default.
- W317383459 hasAuthorship W317383459A5024266611 @default.
- W317383459 hasAuthorship W317383459A5024781173 @default.
- W317383459 hasAuthorship W317383459A5041455638 @default.
- W317383459 hasAuthorship W317383459A5062333532 @default.
- W317383459 hasAuthorship W317383459A5087387214 @default.
- W317383459 hasBestOaLocation W3173834592 @default.
- W317383459 hasConcept C104317684 @default.
- W317383459 hasConcept C121608353 @default.
- W317383459 hasConcept C126322002 @default.
- W317383459 hasConcept C134018914 @default.
- W317383459 hasConcept C150194340 @default.
- W317383459 hasConcept C185592680 @default.
- W317383459 hasConcept C2777164284 @default.
- W317383459 hasConcept C2779066055 @default.
- W317383459 hasConcept C2779742232 @default.
- W317383459 hasConcept C530470458 @default.
- W317383459 hasConcept C55493867 @default.
- W317383459 hasConcept C71924100 @default.
- W317383459 hasConcept C8415881 @default.
- W317383459 hasConcept C84606932 @default.
- W317383459 hasConcept C86803240 @default.
- W317383459 hasConcept C98717036 @default.
- W317383459 hasConceptScore W317383459C104317684 @default.
- W317383459 hasConceptScore W317383459C121608353 @default.
- W317383459 hasConceptScore W317383459C126322002 @default.
- W317383459 hasConceptScore W317383459C134018914 @default.
- W317383459 hasConceptScore W317383459C150194340 @default.
- W317383459 hasConceptScore W317383459C185592680 @default.
- W317383459 hasConceptScore W317383459C2777164284 @default.
- W317383459 hasConceptScore W317383459C2779066055 @default.
- W317383459 hasConceptScore W317383459C2779742232 @default.
- W317383459 hasConceptScore W317383459C530470458 @default.
- W317383459 hasConceptScore W317383459C55493867 @default.
- W317383459 hasConceptScore W317383459C71924100 @default.
- W317383459 hasConceptScore W317383459C8415881 @default.