Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173853907> ?p ?o ?g. }
- W3173853907 endingPage "182" @default.
- W3173853907 startingPage "177" @default.
- W3173853907 abstract "The gastric proton pump (H+,K+-ATPase) responsible for the H+ secretion of gastric acid is an essential therapeutic target for acid-related diseases. H+,K+-ATPase belongs to a P2-type ATPase family. Here, we examined the effects of a newly synthesized dihydropyrazole derivative KYY-008 on the H+,K+-ATPase. KYY-008 concentration-dependently inhibited the enzyme activity of the ATPase in the membrane fractions prepared from isolated hog gastric mucosa and from human kidney HEK293 cells in which gastric H+,K+-ATPase is exogenously expressed. The IC50 values in these samples were 3.4 μM and 3.7 μM, respectively. In addition, KYY-008 significantly inhibited the H+,K+-ATPase-derived H+ uptake into the tightly sealed vesicles prepared from the hog gastric mucosa. In contrast, KYY-008 has no effect on the activities of other P2-type ATPases such as Na+,K+-ATPase and Ca2+-ATPase. KYY-008 did not change the ionic currents of voltage-dependent Ca2+ channels, that were potential targets for some dihydropyrazole derivatives. Together, we discovered a new dihydropyrazole derivative which acts as a selective inhibitor of gastric H+,K+-ATPase." @default.
- W3173853907 created "2021-07-05" @default.
- W3173853907 creator A5001279041 @default.
- W3173853907 creator A5041343512 @default.
- W3173853907 creator A5053529984 @default.
- W3173853907 creator A5055447083 @default.
- W3173853907 creator A5079627883 @default.
- W3173853907 creator A5085879502 @default.
- W3173853907 date "2021-08-01" @default.
- W3173853907 modified "2023-10-16" @default.
- W3173853907 title "Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008" @default.
- W3173853907 cites W1486688825 @default.
- W3173853907 cites W1490607841 @default.
- W3173853907 cites W1493270913 @default.
- W3173853907 cites W1596185709 @default.
- W3173853907 cites W1948496337 @default.
- W3173853907 cites W1967189967 @default.
- W3173853907 cites W1967959893 @default.
- W3173853907 cites W1970147360 @default.
- W3173853907 cites W1970899777 @default.
- W3173853907 cites W1971682920 @default.
- W3173853907 cites W1973886765 @default.
- W3173853907 cites W1975963600 @default.
- W3173853907 cites W2000708353 @default.
- W3173853907 cites W2032946630 @default.
- W3173853907 cites W2038462194 @default.
- W3173853907 cites W2047981316 @default.
- W3173853907 cites W2047989650 @default.
- W3173853907 cites W2052642915 @default.
- W3173853907 cites W2054590403 @default.
- W3173853907 cites W2056217070 @default.
- W3173853907 cites W2062078340 @default.
- W3173853907 cites W2064169979 @default.
- W3173853907 cites W2065122422 @default.
- W3173853907 cites W2067116519 @default.
- W3173853907 cites W2080943178 @default.
- W3173853907 cites W2094532556 @default.
- W3173853907 cites W2145047720 @default.
- W3173853907 cites W2154051665 @default.
- W3173853907 cites W2514562472 @default.
- W3173853907 cites W2794975044 @default.
- W3173853907 cites W2949803452 @default.
- W3173853907 cites W2969881566 @default.
- W3173853907 cites W3161252188 @default.
- W3173853907 doi "https://doi.org/10.1016/j.bbrc.2021.06.056" @default.
- W3173853907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34166915" @default.
- W3173853907 hasPublicationYear "2021" @default.
- W3173853907 type Work @default.
- W3173853907 sameAs 3173853907 @default.
- W3173853907 citedByCount "2" @default.
- W3173853907 countsByYear W31738539072023 @default.
- W3173853907 crossrefType "journal-article" @default.
- W3173853907 hasAuthorship W3173853907A5001279041 @default.
- W3173853907 hasAuthorship W3173853907A5041343512 @default.
- W3173853907 hasAuthorship W3173853907A5053529984 @default.
- W3173853907 hasAuthorship W3173853907A5055447083 @default.
- W3173853907 hasAuthorship W3173853907A5079627883 @default.
- W3173853907 hasAuthorship W3173853907A5085879502 @default.
- W3173853907 hasBestOaLocation W31738539071 @default.
- W3173853907 hasConcept C181199279 @default.
- W3173853907 hasConcept C185592680 @default.
- W3173853907 hasConcept C202751555 @default.
- W3173853907 hasConcept C23265538 @default.
- W3173853907 hasConcept C2777504413 @default.
- W3173853907 hasConcept C2777752497 @default.
- W3173853907 hasConcept C2779422922 @default.
- W3173853907 hasConcept C2781443798 @default.
- W3173853907 hasConcept C2911069308 @default.
- W3173853907 hasConcept C49039625 @default.
- W3173853907 hasConcept C55493867 @default.
- W3173853907 hasConcept C71240020 @default.
- W3173853907 hasConceptScore W3173853907C181199279 @default.
- W3173853907 hasConceptScore W3173853907C185592680 @default.
- W3173853907 hasConceptScore W3173853907C202751555 @default.
- W3173853907 hasConceptScore W3173853907C23265538 @default.
- W3173853907 hasConceptScore W3173853907C2777504413 @default.
- W3173853907 hasConceptScore W3173853907C2777752497 @default.
- W3173853907 hasConceptScore W3173853907C2779422922 @default.
- W3173853907 hasConceptScore W3173853907C2781443798 @default.
- W3173853907 hasConceptScore W3173853907C2911069308 @default.
- W3173853907 hasConceptScore W3173853907C49039625 @default.
- W3173853907 hasConceptScore W3173853907C55493867 @default.
- W3173853907 hasConceptScore W3173853907C71240020 @default.
- W3173853907 hasFunder F4320334764 @default.
- W3173853907 hasLocation W31738539071 @default.
- W3173853907 hasLocation W31738539072 @default.
- W3173853907 hasOpenAccess W3173853907 @default.
- W3173853907 hasPrimaryLocation W31738539071 @default.
- W3173853907 hasRelatedWork W1518627203 @default.
- W3173853907 hasRelatedWork W1985206692 @default.
- W3173853907 hasRelatedWork W2017472773 @default.
- W3173853907 hasRelatedWork W2030660483 @default.
- W3173853907 hasRelatedWork W2032844690 @default.
- W3173853907 hasRelatedWork W2093474665 @default.
- W3173853907 hasRelatedWork W2135261276 @default.
- W3173853907 hasRelatedWork W2288469455 @default.
- W3173853907 hasRelatedWork W343153712 @default.
- W3173853907 hasRelatedWork W391128345 @default.