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- W3173903422 abstract "The manufacture of recombinant therapeutics is a fastest-developing section of therapeutic pharmaceuticals and presently plays a significant role in disease management. Yeasts are established eukaryotic host for heterologous protein production and offer distinctive benefits in synthesising pharmaceutical recombinants. Yeasts are proficient of vigorous growth on inexpensive media, easy for gene manipulations, and are capable of adding post translational changes of eukaryotes. Saccharomyces cerevisiae is model yeast that has been applied as a main host for the manufacture of pharmaceuticals and is the major tool box for genetic studies; nevertheless, numerous other yeasts comprising Pichia pastoris, Kluyveromyces lactis, Hansenula polymorpha, and Yarrowia lipolytica have attained huge attention as non-conventional partners intended for the industrial manufacture of heterologous proteins. Here we review the advances in yeast gene manipulation tools and techniques for heterologous pharmaceutical protein synthesis. Application of secretory pathway engineering, glycosylation engineering strategies and fermentation scale-up strategies in customizing yeast cells for the synthesis of therapeutic proteins has been meticulously described." @default.
- W3173903422 created "2021-07-05" @default.
- W3173903422 creator A5002384477 @default.
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- W3173903422 creator A5084122728 @default.
- W3173903422 creator A5089148923 @default.
- W3173903422 date "2021-06-30" @default.
- W3173903422 modified "2023-10-17" @default.
- W3173903422 title "Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up" @default.
- W3173903422 cites W13893245 @default.
- W3173903422 cites W1516116810 @default.
- W3173903422 cites W1574928346 @default.
- W3173903422 cites W1585108391 @default.
- W3173903422 cites W1802265149 @default.
- W3173903422 cites W1880114654 @default.
- W3173903422 cites W1964146327 @default.
- W3173903422 cites W1967953443 @default.
- W3173903422 cites W1969085279 @default.
- W3173903422 cites W1974770836 @default.
- W3173903422 cites W1976429947 @default.
- W3173903422 cites W1980754871 @default.
- W3173903422 cites W1989880904 @default.
- W3173903422 cites W1991336307 @default.
- W3173903422 cites W1991451972 @default.
- W3173903422 cites W1991602409 @default.
- W3173903422 cites W1995010460 @default.
- W3173903422 cites W1995801067 @default.
- W3173903422 cites W1996270252 @default.
- W3173903422 cites W1997526157 @default.
- W3173903422 cites W1999650838 @default.
- W3173903422 cites W2000702379 @default.
- W3173903422 cites W2001402803 @default.
- W3173903422 cites W2001902274 @default.
- W3173903422 cites W2004547992 @default.
- W3173903422 cites W2006403630 @default.
- W3173903422 cites W2006512810 @default.
- W3173903422 cites W2008165835 @default.
- W3173903422 cites W2008511574 @default.
- W3173903422 cites W2013231418 @default.
- W3173903422 cites W2017653549 @default.
- W3173903422 cites W2023982945 @default.
- W3173903422 cites W2033867130 @default.
- W3173903422 cites W2034766668 @default.
- W3173903422 cites W2035090773 @default.
- W3173903422 cites W2035420256 @default.
- W3173903422 cites W2036834782 @default.
- W3173903422 cites W2037639502 @default.
- W3173903422 cites W2039189206 @default.
- W3173903422 cites W2040477420 @default.
- W3173903422 cites W2040693841 @default.
- W3173903422 cites W2043784202 @default.
- W3173903422 cites W2046437093 @default.
- W3173903422 cites W2046689037 @default.
- W3173903422 cites W2049322319 @default.
- W3173903422 cites W2049350791 @default.
- W3173903422 cites W2050405684 @default.
- W3173903422 cites W2052654155 @default.
- W3173903422 cites W2056127444 @default.
- W3173903422 cites W2057210999 @default.
- W3173903422 cites W2060675341 @default.
- W3173903422 cites W2062035606 @default.
- W3173903422 cites W2062932180 @default.
- W3173903422 cites W2068623317 @default.
- W3173903422 cites W2069679266 @default.
- W3173903422 cites W2070615340 @default.
- W3173903422 cites W2070860497 @default.
- W3173903422 cites W2071768512 @default.
- W3173903422 cites W2071890783 @default.
- W3173903422 cites W2072880369 @default.
- W3173903422 cites W2073581590 @default.
- W3173903422 cites W2074443029 @default.
- W3173903422 cites W2081051355 @default.
- W3173903422 cites W2089312229 @default.
- W3173903422 cites W2090961623 @default.
- W3173903422 cites W2093657906 @default.
- W3173903422 cites W2099521715 @default.
- W3173903422 cites W2100686679 @default.
- W3173903422 cites W2101610620 @default.
- W3173903422 cites W2102328039 @default.
- W3173903422 cites W2102411945 @default.
- W3173903422 cites W2107632694 @default.
- W3173903422 cites W2109370770 @default.
- W3173903422 cites W2109587594 @default.
- W3173903422 cites W2109811686 @default.
- W3173903422 cites W2110796052 @default.
- W3173903422 cites W2111311345 @default.
- W3173903422 cites W2113593535 @default.
- W3173903422 cites W2113633071 @default.
- W3173903422 cites W2115328929 @default.
- W3173903422 cites W2116494308 @default.
- W3173903422 cites W2116575618 @default.
- W3173903422 cites W2117398821 @default.
- W3173903422 cites W2119861230 @default.
- W3173903422 cites W2120357935 @default.