Matches in SemOpenAlex for { <https://semopenalex.org/work/W3173928920> ?p ?o ?g. }
- W3173928920 endingPage "6970" @default.
- W3173928920 startingPage "6958" @default.
- W3173928920 abstract "Abstract Initiation factor IF3 is an essential protein that enhances the fidelity and speed of bacterial mRNA translation initiation. Here, we describe the dynamic interplay between IF3 domains and their alternative binding sites using pre-steady state kinetics combined with molecular modelling of available structures of initiation complexes. Our results show that IF3 accommodates its domains at velocities ranging over two orders of magnitude, responding to the binding of each 30S ligand. IF1 and IF2 promote IF3 compaction and the movement of the C-terminal domain (IF3C) towards the P site. Concomitantly, the N-terminal domain (IF3N) creates a pocket ready to accept the initiator tRNA. Selection of the initiator tRNA is accompanied by a transient accommodation of IF3N towards the 30S platform. Decoding of the mRNA start codon displaces IF3C away from the P site and rate limits translation initiation. 70S initiation complex formation brings IF3 domains in close proximity to each other prior to dissociation and recycling of the factor for a new round of translation initiation. Altogether, our results describe the kinetic spectrum of IF3 movements and highlight functional transitions of the factor that ensure accurate mRNA translation initiation." @default.
- W3173928920 created "2021-07-05" @default.
- W3173928920 creator A5024108673 @default.
- W3173928920 creator A5027692159 @default.
- W3173928920 creator A5042980294 @default.
- W3173928920 creator A5051040373 @default.
- W3173928920 creator A5051117956 @default.
- W3173928920 creator A5052892484 @default.
- W3173928920 creator A5090219370 @default.
- W3173928920 date "2021-06-23" @default.
- W3173928920 modified "2023-10-10" @default.
- W3173928920 title "The dynamic cycle of bacterial translation initiation factor IF3" @default.
- W3173928920 cites W1031578623 @default.
- W3173928920 cites W1498556420 @default.
- W3173928920 cites W1512441902 @default.
- W3173928920 cites W1607931568 @default.
- W3173928920 cites W1973699439 @default.
- W3173928920 cites W1980365471 @default.
- W3173928920 cites W1981021420 @default.
- W3173928920 cites W2005452431 @default.
- W3173928920 cites W2007890475 @default.
- W3173928920 cites W2008545860 @default.
- W3173928920 cites W2025856525 @default.
- W3173928920 cites W2033414595 @default.
- W3173928920 cites W2037213262 @default.
- W3173928920 cites W2037679031 @default.
- W3173928920 cites W2038589110 @default.
- W3173928920 cites W2049997941 @default.
- W3173928920 cites W2056365366 @default.
- W3173928920 cites W2057019696 @default.
- W3173928920 cites W2065283382 @default.
- W3173928920 cites W2066775995 @default.
- W3173928920 cites W2067372033 @default.
- W3173928920 cites W2071804506 @default.
- W3173928920 cites W2073111529 @default.
- W3173928920 cites W2084879105 @default.
- W3173928920 cites W2086957652 @default.
- W3173928920 cites W2124433456 @default.
- W3173928920 cites W2132629607 @default.
- W3173928920 cites W2134233533 @default.
- W3173928920 cites W2134306509 @default.
- W3173928920 cites W2144288821 @default.
- W3173928920 cites W2148504068 @default.
- W3173928920 cites W2149357806 @default.
- W3173928920 cites W2151194410 @default.
- W3173928920 cites W2169017992 @default.
- W3173928920 cites W2264446896 @default.
- W3173928920 cites W2521190274 @default.
- W3173928920 cites W2598981182 @default.
- W3173928920 cites W2759477460 @default.
- W3173928920 cites W2767810627 @default.
- W3173928920 cites W2804822363 @default.
- W3173928920 cites W3035248921 @default.
- W3173928920 cites W4231760081 @default.
- W3173928920 cites W4320577865 @default.
- W3173928920 cites W2754001480 @default.
- W3173928920 doi "https://doi.org/10.1093/nar/gkab522" @default.
- W3173928920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8266586" @default.
- W3173928920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34161576" @default.
- W3173928920 hasPublicationYear "2021" @default.
- W3173928920 type Work @default.
- W3173928920 sameAs 3173928920 @default.
- W3173928920 citedByCount "1" @default.
- W3173928920 countsByYear W31739289202022 @default.
- W3173928920 crossrefType "journal-article" @default.
- W3173928920 hasAuthorship W3173928920A5024108673 @default.
- W3173928920 hasAuthorship W3173928920A5027692159 @default.
- W3173928920 hasAuthorship W3173928920A5042980294 @default.
- W3173928920 hasAuthorship W3173928920A5051040373 @default.
- W3173928920 hasAuthorship W3173928920A5051117956 @default.
- W3173928920 hasAuthorship W3173928920A5052892484 @default.
- W3173928920 hasAuthorship W3173928920A5090219370 @default.
- W3173928920 hasBestOaLocation W31739289201 @default.
- W3173928920 hasConcept C104317684 @default.
- W3173928920 hasConcept C105580179 @default.
- W3173928920 hasConcept C12554922 @default.
- W3173928920 hasConcept C149364088 @default.
- W3173928920 hasConcept C153957851 @default.
- W3173928920 hasConcept C4718897 @default.
- W3173928920 hasConcept C54355233 @default.
- W3173928920 hasConcept C62493599 @default.
- W3173928920 hasConcept C67705224 @default.
- W3173928920 hasConcept C86803240 @default.
- W3173928920 hasConcept C93734116 @default.
- W3173928920 hasConcept C95444343 @default.
- W3173928920 hasConceptScore W3173928920C104317684 @default.
- W3173928920 hasConceptScore W3173928920C105580179 @default.
- W3173928920 hasConceptScore W3173928920C12554922 @default.
- W3173928920 hasConceptScore W3173928920C149364088 @default.
- W3173928920 hasConceptScore W3173928920C153957851 @default.
- W3173928920 hasConceptScore W3173928920C4718897 @default.
- W3173928920 hasConceptScore W3173928920C54355233 @default.
- W3173928920 hasConceptScore W3173928920C62493599 @default.
- W3173928920 hasConceptScore W3173928920C67705224 @default.
- W3173928920 hasConceptScore W3173928920C86803240 @default.
- W3173928920 hasConceptScore W3173928920C93734116 @default.
- W3173928920 hasConceptScore W3173928920C95444343 @default.
- W3173928920 hasFunder F4320324099 @default.