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• W3173967999 abstract "mecA -dependent methicillin resistance in MRSA is subject to regulation by numerous accessory factors involved in cell wall biosynthesis, nucleotide signaling, and central metabolism. Here, we report that mutations in the TCA cycle gene, sucC , increased susceptibility to β-lactam antibiotics and was accompanied by significant accumulation of succinyl-CoA, which in turn perturbed lysine succinylation in the proteome." @default.
• W3173967999 created "2021-07-05" @default.
• W3173967999 creator A5001365238 @default.
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• W3173967999 date "2021-06-29" @default.
• W3173967999 modified "2023-10-15" @default.
• W3173967999 title "Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics" @default.
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• W3173967999 doi "https://doi.org/10.1128/mbio.00530-21" @default.

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