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- W3173991675 abstract "Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals. Inflammasome multiprotein complexes are composed of three parts: a sensor protein, an adaptor, and pro-caspase-1. Activation of the inflammasome leads to the activation of caspase-1, which cleaves pro-inflammatory cytokines such as IL-1β and IL-18, leading to pyroptosis. Effectors of the inflammasome not only provide protection against infectious pathogens, but also mediate control over sterile insults. Aberrant inflammasome signaling has been implicated in the development of cardiovascular and metabolic diseases, cancer, and neurodegenerative disorders. Here, we review the role of the inflammasome as a double-edged sword in various diseases, and the outcomes can be either good or bad depending on the disease, as well as the genetic background. We highlight inflammasome memory and the two-shot activation process. We also propose the M- and N-type inflammation model, and discuss how the inflammasome pathway may be targeted for the development of novel therapy." @default.
- W3173991675 created "2021-07-05" @default.
- W3173991675 creator A5026734340 @default.
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- W3173991675 date "2021-07-02" @default.
- W3173991675 modified "2023-10-18" @default.
- W3173991675 title "Inflammasomes as therapeutic targets in human diseases" @default.
- W3173991675 cites W1529674879 @default.
- W3173991675 cites W1561041814 @default.
- W3173991675 cites W1699821970 @default.
- W3173991675 cites W1784921949 @default.
- W3173991675 cites W1805865584 @default.
- W3173991675 cites W1900592574 @default.
- W3173991675 cites W1906422585 @default.
- W3173991675 cites W1953948364 @default.
- W3173991675 cites W1954263225 @default.
- W3173991675 cites W1964744961 @default.
- W3173991675 cites W1965607649 @default.
- W3173991675 cites W1966914633 @default.
- W3173991675 cites W1969539443 @default.
- W3173991675 cites W1970436087 @default.
- W3173991675 cites W1973603028 @default.
- W3173991675 cites W1975145629 @default.
- W3173991675 cites W1983289600 @default.
- W3173991675 cites W1986685158 @default.
- W3173991675 cites W1986875278 @default.
- W3173991675 cites W1988197452 @default.
- W3173991675 cites W1993442154 @default.
- W3173991675 cites W1993976394 @default.
- W3173991675 cites W1995481571 @default.
- W3173991675 cites W1996150072 @default.
- W3173991675 cites W1998221258 @default.
- W3173991675 cites W1999634145 @default.
- W3173991675 cites W2004447523 @default.
- W3173991675 cites W2004516435 @default.
- W3173991675 cites W2009093325 @default.
- W3173991675 cites W2009523990 @default.
- W3173991675 cites W2014602273 @default.
- W3173991675 cites W2015283405 @default.
- W3173991675 cites W2018607502 @default.
- W3173991675 cites W2019407752 @default.
- W3173991675 cites W2025355874 @default.
- W3173991675 cites W2030919251 @default.
- W3173991675 cites W2030997154 @default.
- W3173991675 cites W2034946303 @default.
- W3173991675 cites W2037142263 @default.
- W3173991675 cites W2041146525 @default.
- W3173991675 cites W2042288276 @default.
- W3173991675 cites W2042816890 @default.
- W3173991675 cites W2042851093 @default.
- W3173991675 cites W2044210137 @default.
- W3173991675 cites W2046088592 @default.
- W3173991675 cites W2049433118 @default.
- W3173991675 cites W2049737588 @default.
- W3173991675 cites W2050516456 @default.
- W3173991675 cites W2051303794 @default.
- W3173991675 cites W2051658957 @default.
- W3173991675 cites W2052874989 @default.
- W3173991675 cites W2055727949 @default.
- W3173991675 cites W2058590329 @default.
- W3173991675 cites W2064874359 @default.
- W3173991675 cites W2068619092 @default.
- W3173991675 cites W2072118838 @default.
- W3173991675 cites W2076063079 @default.
- W3173991675 cites W2079681430 @default.
- W3173991675 cites W2080827095 @default.
- W3173991675 cites W2081916627 @default.
- W3173991675 cites W2082400315 @default.
- W3173991675 cites W2082857443 @default.
- W3173991675 cites W2083236593 @default.
- W3173991675 cites W2084139121 @default.
- W3173991675 cites W2084158898 @default.
- W3173991675 cites W2088110734 @default.
- W3173991675 cites W2088254488 @default.
- W3173991675 cites W2089503694 @default.
- W3173991675 cites W2089714303 @default.
- W3173991675 cites W2090859543 @default.
- W3173991675 cites W2096850113 @default.
- W3173991675 cites W2097893463 @default.
- W3173991675 cites W2098000380 @default.
- W3173991675 cites W2098444146 @default.
- W3173991675 cites W2098854209 @default.
- W3173991675 cites W2098914905 @default.
- W3173991675 cites W2103260279 @default.
- W3173991675 cites W2104195963 @default.
- W3173991675 cites W2105256361 @default.
- W3173991675 cites W2108373994 @default.
- W3173991675 cites W2109789710 @default.
- W3173991675 cites W2113511371 @default.
- W3173991675 cites W2114266096 @default.
- W3173991675 cites W2118403357 @default.
- W3173991675 cites W2118800225 @default.
- W3173991675 cites W2119098586 @default.
- W3173991675 cites W2121175872 @default.