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- W3173996419 abstract "Abstract In Drosophila melanogaster , olfactory projection neurons (PNs) convey odor information from the peripheral olfactory center to higher brain regions. The anatomical and physiological properties of PNs have been well characterized at the cellular and circuit level. The ultrastructural features of PNs remain unknown however, particularly with respect to presynaptic active zones (PAZs) and dense core vesicles (DCVs). In the current study, membrane-labeled electron microscopy was used to volume-reconstruct 89 PN axonal boutons and identify the internal PAZs and DCVs. Based on ultrastructural parameters, these PN boutons could be classified into three morphological distinct subtypes. Interestingly, the distributions of PAZs and DCVs were distinct within these three subtypes. DCVs were enriched in membrane labeled GH146-positive boutons, suggesting that GH146-positive PNs release both neurotransmitters and neuromodulators. The study identified the detailed distributions of PAZs and DCVs in PN boutons and indicates that neuromodulators mediated by DCVs may play an important role in PNs for olfactory processing." @default.
- W3173996419 created "2021-07-05" @default.
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- W3173996419 date "2021-01-13" @default.
- W3173996419 modified "2023-10-06" @default.
- W3173996419 title "Ultrastructural features of presynaptic active zones and dense core vesicles of olfactory projection neuron boutons in Drosophila melanogaster" @default.
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- W3173996419 doi "https://doi.org/10.1101/2021.01.12.426300" @default.
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