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- W3174065582 abstract "There are many unanswered questions regarding serological testing for SARS-CoV-2 including the longevity of the neutralising antibody response and correlation with binding antibodies and subsequent protection. This study evaluated the durability of neutralising antibody response over a 12-month period using the cPass™ SARS-CoV-2 sVNT and correlation with binding antibodies using both the LIAISON® SARS-CoV-2 S1/S2 IgG and Abbott Architect SARS-CoV-2 IgG. 214 samples were evaluated from 81 SARS-CoV-2 NAAT confirmed positive patients collected from March 2020-March 2021 at various time intervals post symptom onset. 120 samples from a reference non-infected population were used for specificity analysis. The cPass™ SARS-CoV-2 sVNT had the highest overall sensitivity 90.3% [CI 84.9, 93.1]. Specificity was comparable to both binding antibody assays, 98.33 [CI 95.4, 99.96]. Sensitivity peaked at 3-6 months post symptom onset at 100% [CI 91.4, 100.0] and persisted up to 9-12 months post infection with sensitivity of 78.8% [CI 62.3, 89.3]. S1/S2 binding antibodies demonstrated satisfactory correlation with RBD neutralising antibodies (Spearman coefficient 0.8937 [CI 0.86,0.92]); nucleocapsid antibodies, however, waned markedly 6 months following infection. There was an association with clinical severity and degree of neutralising antibody response (p=0.0025). No association between age or gender was demonstrated in this study. These results support both the use of the cPass™ SARS-CoV-2 sVNT to assess neutralising antibodies and the possible use S1/S2 binding antibodies as a surrogate for neutralising antibodies in diagnostic laboratories; as well as provides information on durability of neutralising antibody response and kinetics over time as the COVID-19 pandemic unfolds." @default.
- W3174065582 created "2021-07-05" @default.
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- W3174065582 date "2021-07-01" @default.
- W3174065582 modified "2023-09-26" @default.
- W3174065582 title "Comparative evaluation and longevity of neutralising and binding antibodies for SARS-COV-2" @default.
- W3174065582 doi "https://doi.org/10.1016/j.pathol.2021.06.104" @default.
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