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- W3174127523 endingPage "100871" @default.
- W3174127523 startingPage "100871" @default.
- W3174127523 abstract "Calommata signata, a burrowing spider, represents a special type of predation mode in spiders, and its utilization of toxins is different from that of web-weaving spiders and wandering spiders. The existing researches on spider toxins are mainly focused on the web-weaving and wandering spiders, but little attention on that of the burrowing spiders. Through transcriptome sequencing of C. signata venom gland and the remaining part as the counterpart tissue, 25 putative neurotoxin precursors were identified. These most neurotoxins were novel because their low similarities with the known sequences except for that of over 50% similarities in four neuropeptide toxins. The 25 neuropeptide toxins were divided into five families according to the constitution of cysteines for the possible disulfide bonds and the similarities of the deduced amino acid sequences. Besides neuropeptide toxins, other potential toxins in the venom gland were also analyzed. Unlike web-weaving spiders and wandering spiders, only a few neurotoxin genes were significantly expressed in the venom gland of C. signata. In the non-peptide toxin genes, only CsTryp_SPc-1, CsPA2-1, CsVa5-2 and four PDI genes were abundantly expressed in the venom gland. The present study provided an improved understanding on the spider toxin diversity and useful information for the exploitation of spider toxins." @default.
- W3174127523 created "2021-07-05" @default.
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- W3174127523 date "2021-12-01" @default.
- W3174127523 modified "2023-10-16" @default.
- W3174127523 title "Neurotoxins in the venom gland of Calommata signata, a burrowing spider" @default.
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- W3174127523 doi "https://doi.org/10.1016/j.cbd.2021.100871" @default.
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