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- W3174129339 abstract "Abstract The intrinsically disordered region (IDR) is a preserved signature of phytobacterial type III effectors (T3Es). The T3E IDR is thought to mediate unfolding during translocation into the host cell and to avoid host defense by sequence diversification. Here, we demonstrate a mechanism of host subversion via the T3E IDR. We report that the Xanthomonas campestris T3E XopR undergoes liquid-liquid phase separation (LLPS) via multivalent IDR-mediated interactions that hijack the Arabidopsis actin cytoskeleton. XopR is gradually translocated into host cells during infection and forms a macromolecular complex with actin-binding proteins at the cell cortex. By tuning the physical-chemical properties of XopR-complex coacervates, XopR progressively manipulates multiple steps of actin assembly, including formin-mediated nucleation, crosslinking of F-actin, and actin depolymerization, which occurs through competition for actin-depolymerizing factor and depends on constituent stoichiometry. Our findings unravel a sophisticated strategy in which bacterial T3E subverts the host actin cytoskeleton via protein complex coacervation." @default.
- W3174129339 created "2021-07-05" @default.
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- W3174129339 date "2021-07-01" @default.
- W3174129339 modified "2023-10-17" @default.
- W3174129339 title "Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation" @default.
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- W3174129339 doi "https://doi.org/10.1038/s41467-021-24375-3" @default.
- W3174129339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8249405" @default.
- W3174129339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34210966" @default.
- W3174129339 hasPublicationYear "2021" @default.
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