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• W3174133783 abstract "The hippocampal formation plays essential roles in learning and memory, and spatial navigation. Although the general anatomy and circuit organization of hippocampal CA1 has been well-studied, most of our understanding of hippocampal circuits comes from the conventional anatomical tracing studies which lack cell-type specificity and quantitative measurements of connectional strengths. New advances in virology and molecular genetics complement traditional approaches and are powerful tools for mapping cell-type-specific circuit connectivity and function. Using monosynaptic rabies tracing, we recently discovered a non-canonical but significant set of back-projections comprised of both excitatory and inhibitory elements from the subiculum to CA1 in the mouse. This discovery suggests previously unconsidered functional roles for direct subicular modulation of hippocampal CA1 circuit activity. In this talk, I will first report our quantitative analysis of canonical- and non-canonical inputs to excitatory neurons in dorsal hippocampal CA1. We find that comparable strength of subiculum complex and entorhinal cortex (EC) inputs to CA1, significant inputs from presubiculum and parasubiculum to CA1, and a threefold stronger input to proximal versus distal CA1 from CA3. Non-canonical subicular complex inputs exhibit opposing topographic connectivity gradients whereby the subiculum-CA1 input strength systematically increases but the presubiculum-CA1 input strength decreases along the proximal-distal axis. These results reveal a novel anatomical framework by which to determine the circuit bases for CA1 physiological representations. Further, to test the hypothesis that CA1-projecting subiculum neurons integrate strong CA1 and local subicular inputs to exert direct feedback regulation of CA1 circuit activity, we map and compare global circuit input and output connections of CA1-projecting and other excitatory subicular neurons using retrograde monosynaptic rabies tracing and anterograde directed herpes simplex virus (H129 strain) in intact brains, respectively. In conjunction with behavior analysis and genetically targeted neuronal activation and inactivation, in vivo GCaMP6-based calcium imaging of CA1 neurons in freely moving animals is used to resolve how CA1-projecting subicular neurons modulate CA1 place cell activity and how they contribute to location dependent learning and memory. Together, these studies provide new insights into this subicular-CA1 pathway, and advance our understanding of how the subiculum interacts with CA1 to regulate hippocampal circuit activity and learning and memory behaviors. Support or Funding Information This research is supported by the National Institutes of Health grant (R01NS078434). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
• W3174133783 created "2021-07-05" @default.
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• W3174133783 date "2018-04-01" @default.
• W3174133783 modified "2023-10-17" @default.
• W3174133783 title "New Hippocampal Circuit Organization Revealed by Viral‐genetic Tracing and Functional Circuit Mapping" @default.
• W3174133783 doi "https://doi.org/10.1096/fasebj.2018.32.1_supplement.93.1" @default.
• W3174133783 hasPublicationYear "2018" @default.
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