Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174150007> ?p ?o ?g. }
- W3174150007 abstract "Pancreatic cancer is a lethal condition with poor outcomes and an increasing incidence. The unfavourable prognosis is due to the lack of early symptoms and consequent late diagnosis. An effective method for the early diagnosis of pancreatic cancer is therefore sought by many researchers in the field. Heparan sulfated proteoglycan-related genes are often expressed differently in tumors than in normal tissues. Alteration of the tumor microenvironment is correlated with the ability of heparan sulfated proteoglycans to bind cytokines and growth factors and eventually to influence tumor progression. Here we discuss the importance of glypicans, syndecans, perlecan and extracellular matrix modifying enzymes, such as heparanases and sulfatases, as potential diagnostics in pancreatic cancer. We also ran an analysis on a multidimensional cancer genomics database for heparan sulfated proteoglycan-related genes, and report altered expression of some of them." @default.
- W3174150007 created "2021-07-05" @default.
- W3174150007 creator A5022820593 @default.
- W3174150007 creator A5084001430 @default.
- W3174150007 date "2021-06-25" @default.
- W3174150007 modified "2023-10-12" @default.
- W3174150007 title "Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer" @default.
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- W3174150007 doi "https://doi.org/10.3389/fonc.2021.695858" @default.
- W3174150007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8267412" @default.
- W3174150007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34249755" @default.
- W3174150007 hasPublicationYear "2021" @default.
- W3174150007 type Work @default.