FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174181788> ?p ?o ?g. }

• W3174181788 endingPage "2334" @default.
• W3174181788 startingPage "2299" @default.
• W3174181788 abstract "Given the strong trend to implement zebrafish (Danio rerio) embryos as translational model not only in ecotoxicological, but also toxicological testing strategies, there is an increasing need for a better understanding of their capacity for xenobiotic biotransformation. With respect to the extrapolation of toxicological data from zebrafish embryos to other life stages or even other organisms, qualitative and quantitative differences in biotransformation pathways, above all in cytochrome P450-dependent (CYP) phase I biotransformation, may lead to over- or underestimation of the hazard and risk certain xenobiotic compounds may pose to later developmental stages or other species. This review provides a comprehensive state-of-the-art overview of the scientific knowledge on the development of the CYP1-4 families and corresponding phase I biotransformation and bioactivation capacities in zebrafish. A total of 68 publications dealing with spatiotemporal CYP mRNA expression patterns, activities towards mammalian CYP-probe substrates, bioactivation and detoxification activities, as well as metabolite profiling were analyzed and included in this review. The main results allow for the following conclusions: (1) Extensive work has been done to document mRNA expression of CYP isoforms from earliest embryonic stages of zebrafish, but juvenile and adult zebrafish have been largely neglected so far. (2) There is insufficient understanding of how sex- and developmental stage-related differences in expression levels of certain CYP isoforms may impact biotransformation and bioactivation capacities in the respective sexes and in different developmental stages of zebrafish. (3) Albeit qualitatively often identical, many studies revealed quantitative differences in metabolic activities of zebrafish embryos and later developmental stages. However, the actual relevance of age-related differences on the outcome of toxicological studies still needs to be clarified. (4) With respect to current remaining gaps, there is still an urgent need for further studies systematically assessing metabolic profiles and capacities of CYP isoforms in zebrafish. Given the increasing importance of Adverse Outcome Pathway (AOP) concepts, an improved understanding of CYP capacities appears essential for the interpretation and outcome of (eco)toxicological studies." @default.
• W3174181788 created "2021-07-05" @default.
• W3174181788 creator A5042450452 @default.
• W3174181788 creator A5078032989 @default.
• W3174181788 date "2021-06-20" @default.
• W3174181788 modified "2023-09-26" @default.
• W3174181788 title "Cytochrome P450-dependent biotransformation capacities in embryonic, juvenile and adult stages of zebrafish (Danio rerio)—a state-of-the-art review" @default.
• W3174181788 cites W101728102 @default.
• W3174181788 cites W1543944128 @default.
• W3174181788 cites W1573917217 @default.
• W3174181788 cites W1751132153 @default.
• W3174181788 cites W1884700913 @default.
• W3174181788 cites W192742334 @default.
• W3174181788 cites W1961074127 @default.
• W3174181788 cites W1969712562 @default.
• W3174181788 cites W1970389989 @default.
• W3174181788 cites W1970741892 @default.
• W3174181788 cites W1971800064 @default.
• W3174181788 cites W1972733233 @default.
• W3174181788 cites W1974356820 @default.
• W3174181788 cites W1981203151 @default.
• W3174181788 cites W1985009935 @default.
• W3174181788 cites W1985484130 @default.
• W3174181788 cites W1992475241 @default.
• W3174181788 cites W1999289347 @default.
• W3174181788 cites W2000871541 @default.
• W3174181788 cites W2005819186 @default.
• W3174181788 cites W2006424018 @default.
• W3174181788 cites W2008184230 @default.
• W3174181788 cites W2009938151 @default.
• W3174181788 cites W2010065230 @default.
• W3174181788 cites W2010430992 @default.
• W3174181788 cites W2014805765 @default.
• W3174181788 cites W2020251842 @default.
• W3174181788 cites W2024127718 @default.
• W3174181788 cites W2030382945 @default.
• W3174181788 cites W2032104863 @default.
• W3174181788 cites W2034863538 @default.
• W3174181788 cites W2035091931 @default.
• W3174181788 cites W2035673046 @default.
• W3174181788 cites W2038576120 @default.
• W3174181788 cites W2038867260 @default.
• W3174181788 cites W2042722144 @default.
• W3174181788 cites W2043652542 @default.
• W3174181788 cites W2044659559 @default.
• W3174181788 cites W2046644529 @default.
• W3174181788 cites W2046978662 @default.
• W3174181788 cites W2052959313 @default.
• W3174181788 cites W2057607519 @default.
• W3174181788 cites W2058601450 @default.
• W3174181788 cites W2058716924 @default.
• W3174181788 cites W2059045499 @default.
• W3174181788 cites W2061476180 @default.
• W3174181788 cites W2066197847 @default.
• W3174181788 cites W2071240538 @default.
• W3174181788 cites W2071292510 @default.
• W3174181788 cites W2072339186 @default.
• W3174181788 cites W2077331899 @default.
• W3174181788 cites W2083080778 @default.
• W3174181788 cites W2087413883 @default.
• W3174181788 cites W2089550859 @default.
• W3174181788 cites W2090900844 @default.
• W3174181788 cites W2092854154 @default.
• W3174181788 cites W2096482948 @default.
• W3174181788 cites W2100117732 @default.
• W3174181788 cites W2104768583 @default.
• W3174181788 cites W2105089678 @default.
• W3174181788 cites W2105623987 @default.
• W3174181788 cites W2106195907 @default.
• W3174181788 cites W2113274670 @default.
• W3174181788 cites W2115300036 @default.
• W3174181788 cites W2130338393 @default.
• W3174181788 cites W2140656258 @default.
• W3174181788 cites W2147971048 @default.
• W3174181788 cites W2148989249 @default.
• W3174181788 cites W2149339192 @default.
• W3174181788 cites W2150946709 @default.
• W3174181788 cites W2155059289 @default.
• W3174181788 cites W2157039168 @default.
• W3174181788 cites W2158406641 @default.
• W3174181788 cites W2158582563 @default.
• W3174181788 cites W2168484164 @default.
• W3174181788 cites W2170195945 @default.
• W3174181788 cites W2189571762 @default.
• W3174181788 cites W2268381236 @default.
• W3174181788 cites W2292088574 @default.
• W3174181788 cites W2322012164 @default.
• W3174181788 cites W2323697199 @default.
• W3174181788 cites W2339564904 @default.
• W3174181788 cites W2477268349 @default.
• W3174181788 cites W2486661956 @default.
• W3174181788 cites W2498970005 @default.
• W3174181788 cites W2510775794 @default.
• W3174181788 cites W2522424083 @default.
• W3174181788 cites W2550980411 @default.
• W3174181788 cites W2564874325 @default.
• W3174181788 cites W2568194525 @default.
• W3174181788 cites W2580337984 @default.

• next