FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174208566> ?p ?o ?g. }

• W3174208566 endingPage "220" @default.
• W3174208566 startingPage "213" @default.
• W3174208566 abstract "PURPOSE:Accumulation of senescent endothelial cells (ECs) and development of vascular aging have been implicated in the etiology of vascular dysfunction and disease. Aerobic exercise has been recognized as the single most effective non-pharmacological anti-aging intervention via increased laminar shear stress (LSS). This study aimed to determine the protective effects of LSS against premature senescence and the underlying mechanism.METHODS: Carotid artery partial ligation surgery was performed on the left carotid arteries (LCAs) of C57BL/6J male mice to determine the effect of disturbed flow on the development of endothelial senescence. Senescence-associated β-galactosidase (SA-β-gal) staining was performed to measure cellular senescence. Expression levels of protein markers for cell senescence including p21, p16, and p53 were measured by western blotting.RESULTS: <i>En face</i> SA-β-gal staining was identified only in the partially ligated LCAs of voluntary wheel-running mice, suggesting a direct relevance of LSS on the prevention of vascular senescence. In the <i>in vitro</i> H₂O₂-induced premature senescence model, preconditioning of high-flow LSS (20 dyne/cm2, 36 hours) induced significant reduction in the percentage of SA-β-gal positive ECs. Expression of the molecular markers of cellular senescence such as p21, p16, and p53 was significantly decreased by LSS pretreatment. However, the protective effects of LSS against premature senescence were completely abolished by SIRT1 inhibition.CONCLUSIONS: The results suggest that high-flow LSS has protective effects against oxidative stress-induced premature endothelial senescence through a SIRT1-dependent mechanism." @default.
• W3174208566 created "2021-07-05" @default.
• W3174208566 creator A5012153191 @default.
• W3174208566 creator A5037781210 @default.
• W3174208566 creator A5043357042 @default.
• W3174208566 creator A5072367924 @default.
• W3174208566 date "2021-05-31" @default.
• W3174208566 modified "2023-09-25" @default.
• W3174208566 title "Laminar Shear Stress Protects Against Premature Endothelial Senescence by SIRT1-Dependent Mechanisms" @default.
• W3174208566 cites W1839057479 @default.
• W3174208566 cites W1975611015 @default.
• W3174208566 cites W1976307356 @default.
• W3174208566 cites W1988960591 @default.
• W3174208566 cites W1995175684 @default.
• W3174208566 cites W2023696449 @default.
• W3174208566 cites W2055019461 @default.
• W3174208566 cites W2065577350 @default.
• W3174208566 cites W2068223162 @default.
• W3174208566 cites W2070865083 @default.
• W3174208566 cites W2081604319 @default.
• W3174208566 cites W2084621368 @default.
• W3174208566 cites W2087877227 @default.
• W3174208566 cites W2097155911 @default.
• W3174208566 cites W2099219058 @default.
• W3174208566 cites W2099361886 @default.
• W3174208566 cites W2099806958 @default.
• W3174208566 cites W2102548818 @default.
• W3174208566 cites W2102802702 @default.
• W3174208566 cites W2104908670 @default.
• W3174208566 cites W2106781693 @default.
• W3174208566 cites W2112540241 @default.
• W3174208566 cites W2118964113 @default.
• W3174208566 cites W2121141378 @default.
• W3174208566 cites W2132872115 @default.
• W3174208566 cites W2136242238 @default.
• W3174208566 cites W2148122374 @default.
• W3174208566 cites W2153059926 @default.
• W3174208566 cites W2155245588 @default.
• W3174208566 cites W2157145576 @default.
• W3174208566 doi "https://doi.org/10.15857/ksep.2021.30.2.213" @default.
• W3174208566 hasPublicationYear "2021" @default.
• W3174208566 type Work @default.
• W3174208566 sameAs 3174208566 @default.
• W3174208566 citedByCount "1" @default.
• W3174208566 countsByYear W31742085662022 @default.
• W3174208566 crossrefType "journal-article" @default.
• W3174208566 hasAuthorship W3174208566A5012153191 @default.
• W3174208566 hasAuthorship W3174208566A5037781210 @default.
• W3174208566 hasAuthorship W3174208566A5043357042 @default.
• W3174208566 hasAuthorship W3174208566A5072367924 @default.
• W3174208566 hasBestOaLocation W31742085661 @default.
• W3174208566 hasConcept C126322002 @default.
• W3174208566 hasConcept C134018914 @default.
• W3174208566 hasConcept C185592680 @default.
• W3174208566 hasConcept C2776151105 @default.
• W3174208566 hasConcept C2780972559 @default.
• W3174208566 hasConcept C522857546 @default.
• W3174208566 hasConcept C71924100 @default.
• W3174208566 hasConcept C86803240 @default.
• W3174208566 hasConceptScore W3174208566C126322002 @default.
• W3174208566 hasConceptScore W3174208566C134018914 @default.
• W3174208566 hasConceptScore W3174208566C185592680 @default.
• W3174208566 hasConceptScore W3174208566C2776151105 @default.
• W3174208566 hasConceptScore W3174208566C2780972559 @default.
• W3174208566 hasConceptScore W3174208566C522857546 @default.
• W3174208566 hasConceptScore W3174208566C71924100 @default.
• W3174208566 hasConceptScore W3174208566C86803240 @default.
• W3174208566 hasFunder F4320321408 @default.
• W3174208566 hasFunder F4320322120 @default.
• W3174208566 hasFunder F4320337338 @default.
• W3174208566 hasIssue "2" @default.
• W3174208566 hasLocation W31742085661 @default.
• W3174208566 hasOpenAccess W3174208566 @default.
• W3174208566 hasPrimaryLocation W31742085661 @default.
• W3174208566 hasRelatedWork W2015114583 @default.
• W3174208566 hasRelatedWork W2042780225 @default.
• W3174208566 hasRelatedWork W2110374371 @default.
• W3174208566 hasRelatedWork W2137989376 @default.
• W3174208566 hasRelatedWork W2145618820 @default.
• W3174208566 hasRelatedWork W2293278356 @default.
• W3174208566 hasRelatedWork W2320354882 @default.
• W3174208566 hasRelatedWork W2624598165 @default.
• W3174208566 hasRelatedWork W2748952813 @default.
• W3174208566 hasRelatedWork W2792027682 @default.
• W3174208566 hasVolume "30" @default.
• W3174208566 isParatext "false" @default.
• W3174208566 isRetracted "false" @default.
• W3174208566 magId "3174208566" @default.
• W3174208566 workType "article" @default.