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- W3174212634 abstract "This study investigated the action of exogenously administered H2S on mean arterial pressure (MAP), heart rate (HR) and renal function in combined states of hypertension and diabetes. Groups (n=6) of spontaneously hypertensive rats (SHR) or DOCA salt hypertensive (DOCA) rats received vehicle, streptozotocin (STZ) or STZ plus Sodium Hydrogen Sulphide (NaHS), at 56μmol/Kg i.p daily for 35 days; theerafter, MAP, HR and GFR were measured in Ketamine + Xylazine anaesthetized rats. Data, mean±SEM, were subjected to ANOVA and significance set at p<0.05. MAP of SHR-STZ was higher than DOCA-STZ (145±2 vs 155±2) (p<0.05) whereas it was similar in the SHR-STZ-NaHS (132±3 mmHg) and DOCA-STZ-NaHS groups. HR of SHR-STZ at 343±5 b/minwas higher than DOCA-STZ 314±7b/min (p<0.05) but was similar (312±19b/min) in SHR-STZ-NaHS vs DOCA-STZ-NaHS. GFR of DOCA-STZ was lower than SHR-STZ (0.5±0.03 vs 1.1±0.1ml/min/100g) whereas SHR-STZ-NaHS was 66% higher than that of DOCA-STZ-NaHS (p<0.05). Improved cardiovascular function with NaHS was likely due to decreased HR and reduced renovascular resistance through vasodilation in both DOCA and SHR concomitant with the development of diabetes." @default.
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- W3174212634 date "2012-04-01" @default.
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- W3174212634 title "EFFECT OF EXOGENOUSLY ADMINISTERED H2S ON THE CARDIAC AND RENAL FUNCTION IN HYPERTENSIVE DIABETIC RATS" @default.
- W3174212634 doi "https://doi.org/10.1096/fasebj.26.1_supplement.876.7" @default.
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