Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174226827> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W3174226827 abstract "Background Acrolein is a common environmental, food and water pollutant and a major component of cigarette smoke. It is produced endogenously by the metabolism of several drugs and amino acids and has also been identified as both a product and initiator of lipid peroxidation. Acrolein is known to be cytotoxic to many cell types including hepatocytes; however the underlying molecular mechanisms are not fully understood. Methods Human hepatic cells (HepG2) were used to measure acrolein-induced hepatotoxicity, and to study endoplasmic reticulum stress (ERS) and mitochondrial death pathways and the induction of apoptosis. Results and Conclusions Acrolein exposure caused a dose-dependent decrease in intracellular antioxidant glutathione and a loss of survival of hepatic cells. Cell death was apoptotic at moderate and necrotic at higher cytotoxic concentrations of acrolein. Additionally, acrolein disrupted mitochondrial integrity/function as seen by fluorescence microscopy and ATP depletion. Acrolein activated ERS proteins PERK, eIF2α and ATF3, 4, 6, and also activated the kinases JNK and p38 MAPK. We postulate that acrolein induced disruption of both mitochondria and ER contributes to hepatotoxicity. Our study defines basic mechanisms involved in liver injury due to oxidative stress molecules and reactive aldehyde pollutants such as acrolein. This study was funded by NIH and VA." @default.
- W3174226827 created "2021-07-05" @default.
- W3174226827 creator A5012100988 @default.
- W3174226827 creator A5020633342 @default.
- W3174226827 creator A5027897501 @default.
- W3174226827 creator A5072732141 @default.
- W3174226827 creator A5085675358 @default.
- W3174226827 date "2011-04-01" @default.
- W3174226827 modified "2023-09-27" @default.
- W3174226827 title "Acrolein‐induced hepatotoxicity: role of mitochondrial dysfunction and endoplasmic reticulum stress" @default.
- W3174226827 doi "https://doi.org/10.1096/fasebj.25.1_supplement.1018.8" @default.
- W3174226827 hasPublicationYear "2011" @default.
- W3174226827 type Work @default.
- W3174226827 sameAs 3174226827 @default.
- W3174226827 citedByCount "0" @default.
- W3174226827 crossrefType "journal-article" @default.
- W3174226827 hasAuthorship W3174226827A5012100988 @default.
- W3174226827 hasAuthorship W3174226827A5020633342 @default.
- W3174226827 hasAuthorship W3174226827A5027897501 @default.
- W3174226827 hasAuthorship W3174226827A5072732141 @default.
- W3174226827 hasAuthorship W3174226827A5085675358 @default.
- W3174226827 hasConcept C139447449 @default.
- W3174226827 hasConcept C158617107 @default.
- W3174226827 hasConcept C161790260 @default.
- W3174226827 hasConcept C185592680 @default.
- W3174226827 hasConcept C2780422782 @default.
- W3174226827 hasConcept C28859421 @default.
- W3174226827 hasConcept C55493867 @default.
- W3174226827 hasConcept C71924100 @default.
- W3174226827 hasConcept C86803240 @default.
- W3174226827 hasConcept C95444343 @default.
- W3174226827 hasConceptScore W3174226827C139447449 @default.
- W3174226827 hasConceptScore W3174226827C158617107 @default.
- W3174226827 hasConceptScore W3174226827C161790260 @default.
- W3174226827 hasConceptScore W3174226827C185592680 @default.
- W3174226827 hasConceptScore W3174226827C2780422782 @default.
- W3174226827 hasConceptScore W3174226827C28859421 @default.
- W3174226827 hasConceptScore W3174226827C55493867 @default.
- W3174226827 hasConceptScore W3174226827C71924100 @default.
- W3174226827 hasConceptScore W3174226827C86803240 @default.
- W3174226827 hasConceptScore W3174226827C95444343 @default.
- W3174226827 hasFunder F4320306127 @default.
- W3174226827 hasFunder F4320332161 @default.
- W3174226827 hasIssue "S1" @default.
- W3174226827 hasLocation W31742268271 @default.
- W3174226827 hasOpenAccess W3174226827 @default.
- W3174226827 hasPrimaryLocation W31742268271 @default.
- W3174226827 hasRelatedWork W1994289493 @default.
- W3174226827 hasRelatedWork W1996952569 @default.
- W3174226827 hasRelatedWork W2127356527 @default.
- W3174226827 hasRelatedWork W2151417687 @default.
- W3174226827 hasRelatedWork W2884569230 @default.
- W3174226827 hasRelatedWork W2946174637 @default.
- W3174226827 hasRelatedWork W3034386412 @default.
- W3174226827 hasRelatedWork W3120897771 @default.
- W3174226827 hasRelatedWork W3138176027 @default.
- W3174226827 hasRelatedWork W3215296738 @default.
- W3174226827 hasVolume "25" @default.
- W3174226827 isParatext "false" @default.
- W3174226827 isRetracted "false" @default.
- W3174226827 magId "3174226827" @default.
- W3174226827 workType "article" @default.