Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174229317> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3174229317 abstract "Vesicle-mediated cargo transport within the endomembrane system requires precise coordination between adaptor molecules, which recognize sorting signals on substrates, and factors that promote changes in membrane architecture. At endosomal compartments, a set of protein complexes collectively known as the ESCRT machinery sequesters transmembrane cargoes that harbor a ubiquitin modification and packages them into vesicles that bud into the endosome lumen. Using atomic force microscopy, we define the architecture of each ESCRT complex in the presence of physiologically relevant lipid bilayers. This analysis indicates that ESCRT-0, ESCRT-I, and ESCRT-II function as heterotetrameric complexes that collectively bind and sequester ubiquitin-modified cargoes. Additionally, our analysis reveals a mechanism by which ESCRT-III membrane scission activity is both spatially and temporally regulated during multivesicular endosome biogenesis. A revised model describing ESCRT function during protein sorting in the endocytic pathway will be presented." @default.
- W3174229317 created "2021-07-05" @default.
- W3174229317 creator A5003857438 @default.
- W3174229317 creator A5015621931 @default.
- W3174229317 creator A5040897967 @default.
- W3174229317 creator A5059065042 @default.
- W3174229317 creator A5090978275 @default.
- W3174229317 date "2012-04-01" @default.
- W3174229317 modified "2023-10-16" @default.
- W3174229317 title "Mechanisms of ESCRT‐mediated cargo sorting and degradation" @default.
- W3174229317 doi "https://doi.org/10.1096/fasebj.26.1_supplement.463.1" @default.
- W3174229317 hasPublicationYear "2012" @default.
- W3174229317 type Work @default.
- W3174229317 sameAs 3174229317 @default.
- W3174229317 citedByCount "1" @default.
- W3174229317 countsByYear W31742293172021 @default.
- W3174229317 crossrefType "journal-article" @default.
- W3174229317 hasAuthorship W3174229317A5003857438 @default.
- W3174229317 hasAuthorship W3174229317A5015621931 @default.
- W3174229317 hasAuthorship W3174229317A5040897967 @default.
- W3174229317 hasAuthorship W3174229317A5059065042 @default.
- W3174229317 hasAuthorship W3174229317A5090978275 @default.
- W3174229317 hasConcept C102747710 @default.
- W3174229317 hasConcept C104317684 @default.
- W3174229317 hasConcept C130316041 @default.
- W3174229317 hasConcept C131934819 @default.
- W3174229317 hasConcept C143876685 @default.
- W3174229317 hasConcept C145059251 @default.
- W3174229317 hasConcept C1491633281 @default.
- W3174229317 hasConcept C170493617 @default.
- W3174229317 hasConcept C185592680 @default.
- W3174229317 hasConcept C20518536 @default.
- W3174229317 hasConcept C206052861 @default.
- W3174229317 hasConcept C24530287 @default.
- W3174229317 hasConcept C25602115 @default.
- W3174229317 hasConcept C2778283623 @default.
- W3174229317 hasConcept C28005876 @default.
- W3174229317 hasConcept C41625074 @default.
- W3174229317 hasConcept C55493867 @default.
- W3174229317 hasConcept C57581600 @default.
- W3174229317 hasConcept C79747257 @default.
- W3174229317 hasConcept C79879829 @default.
- W3174229317 hasConcept C86803240 @default.
- W3174229317 hasConcept C95444343 @default.
- W3174229317 hasConceptScore W3174229317C102747710 @default.
- W3174229317 hasConceptScore W3174229317C104317684 @default.
- W3174229317 hasConceptScore W3174229317C130316041 @default.
- W3174229317 hasConceptScore W3174229317C131934819 @default.
- W3174229317 hasConceptScore W3174229317C143876685 @default.
- W3174229317 hasConceptScore W3174229317C145059251 @default.
- W3174229317 hasConceptScore W3174229317C1491633281 @default.
- W3174229317 hasConceptScore W3174229317C170493617 @default.
- W3174229317 hasConceptScore W3174229317C185592680 @default.
- W3174229317 hasConceptScore W3174229317C20518536 @default.
- W3174229317 hasConceptScore W3174229317C206052861 @default.
- W3174229317 hasConceptScore W3174229317C24530287 @default.
- W3174229317 hasConceptScore W3174229317C25602115 @default.
- W3174229317 hasConceptScore W3174229317C2778283623 @default.
- W3174229317 hasConceptScore W3174229317C28005876 @default.
- W3174229317 hasConceptScore W3174229317C41625074 @default.
- W3174229317 hasConceptScore W3174229317C55493867 @default.
- W3174229317 hasConceptScore W3174229317C57581600 @default.
- W3174229317 hasConceptScore W3174229317C79747257 @default.
- W3174229317 hasConceptScore W3174229317C79879829 @default.
- W3174229317 hasConceptScore W3174229317C86803240 @default.
- W3174229317 hasConceptScore W3174229317C95444343 @default.
- W3174229317 hasIssue "S1" @default.
- W3174229317 hasLocation W31742293171 @default.
- W3174229317 hasOpenAccess W3174229317 @default.
- W3174229317 hasPrimaryLocation W31742293171 @default.
- W3174229317 hasRelatedWork W1985826913 @default.
- W3174229317 hasRelatedWork W2012844441 @default.
- W3174229317 hasRelatedWork W2032457548 @default.
- W3174229317 hasRelatedWork W2049369927 @default.
- W3174229317 hasRelatedWork W2104950526 @default.
- W3174229317 hasRelatedWork W2109691647 @default.
- W3174229317 hasRelatedWork W2142792452 @default.
- W3174229317 hasRelatedWork W2164532457 @default.
- W3174229317 hasRelatedWork W3027749399 @default.
- W3174229317 hasRelatedWork W3174229317 @default.
- W3174229317 hasVolume "26" @default.
- W3174229317 isParatext "false" @default.
- W3174229317 isRetracted "false" @default.
- W3174229317 magId "3174229317" @default.
- W3174229317 workType "article" @default.