Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174229932> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3174229932 abstract "Norepinephrine (NE) has been shown to have profound effects on epileptogenesis. The CA3 region of the hippocampus is believed to be a common focus in temporal lobe epilepsy, generating a type of epileptiform activity which propagates throughout the brain. Our previous work suggests that NE attenuates CA3 burst discharge activity by activating an α2 adrenergic receptor (AR) expressed on hippocampal CA3 pyramidal cells. To characterize the α2AR responsible for decreasing hippocampal epileptiform activity; a pharmacological profile for various α2AR agonists was generated. EC50 values obtained were consistent with an α2AR-mediated response. To confirm the involvement of α2ARs, Schild regressions were constructed from concentration-response curves using the AR agonist epinephrine in the presence of the selective α2AR antagonist RS79948. The pA2 values obtained correlated with affinity values for α2ARs. Similar experiments were performed in the presence of subtype-selective α2AR antagonists. pA2 values obtained from rauwolscine, BRL44408 and ARC 239, correlated with affinities for the α2AAR. Surgical and pharmacological isolation of CA3 pyramidal neurons suggest that NE is acting locally on these cells. These results suggest that NE is directly inhibiting hippocampal CA3 burst activity through the α2AAR. Insight into this effect may lead to a greater understanding of how NE modulates hippocampal networks and its role in epilepsy. This study was funded by NSF CAREER Award 0347259 (VAD), ND EPSCoR through NSF EPS-0447679 (VAD) and NIH 5P20RR017699 from the COBRE program (JEP, VAD)." @default.
- W3174229932 created "2021-07-05" @default.
- W3174229932 creator A5020548748 @default.
- W3174229932 creator A5022677182 @default.
- W3174229932 creator A5025879492 @default.
- W3174229932 creator A5032240532 @default.
- W3174229932 creator A5032925328 @default.
- W3174229932 creator A5041537880 @default.
- W3174229932 creator A5078415178 @default.
- W3174229932 creator A5084500125 @default.
- W3174229932 date "2006-03-01" @default.
- W3174229932 modified "2023-09-23" @default.
- W3174229932 title "α 2 Adrenergic Modulation of Hippocampal CA3 Network Activity" @default.
- W3174229932 doi "https://doi.org/10.1096/fasebj.20.4.a253-a" @default.
- W3174229932 hasPublicationYear "2006" @default.
- W3174229932 type Work @default.
- W3174229932 sameAs 3174229932 @default.
- W3174229932 citedByCount "0" @default.
- W3174229932 crossrefType "journal-article" @default.
- W3174229932 hasAuthorship W3174229932A5020548748 @default.
- W3174229932 hasAuthorship W3174229932A5022677182 @default.
- W3174229932 hasAuthorship W3174229932A5025879492 @default.
- W3174229932 hasAuthorship W3174229932A5032240532 @default.
- W3174229932 hasAuthorship W3174229932A5032925328 @default.
- W3174229932 hasAuthorship W3174229932A5041537880 @default.
- W3174229932 hasAuthorship W3174229932A5078415178 @default.
- W3174229932 hasAuthorship W3174229932A5084500125 @default.
- W3174229932 hasConcept C126322002 @default.
- W3174229932 hasConcept C134018914 @default.
- W3174229932 hasConcept C148762608 @default.
- W3174229932 hasConcept C169760540 @default.
- W3174229932 hasConcept C170493617 @default.
- W3174229932 hasConcept C176233148 @default.
- W3174229932 hasConcept C185592680 @default.
- W3174229932 hasConcept C2775864247 @default.
- W3174229932 hasConcept C2776504411 @default.
- W3174229932 hasConcept C2776885963 @default.
- W3174229932 hasConcept C2777676773 @default.
- W3174229932 hasConcept C2778186239 @default.
- W3174229932 hasConcept C2778938600 @default.
- W3174229932 hasConcept C2781161787 @default.
- W3174229932 hasConcept C57236427 @default.
- W3174229932 hasConcept C71924100 @default.
- W3174229932 hasConcept C86803240 @default.
- W3174229932 hasConceptScore W3174229932C126322002 @default.
- W3174229932 hasConceptScore W3174229932C134018914 @default.
- W3174229932 hasConceptScore W3174229932C148762608 @default.
- W3174229932 hasConceptScore W3174229932C169760540 @default.
- W3174229932 hasConceptScore W3174229932C170493617 @default.
- W3174229932 hasConceptScore W3174229932C176233148 @default.
- W3174229932 hasConceptScore W3174229932C185592680 @default.
- W3174229932 hasConceptScore W3174229932C2775864247 @default.
- W3174229932 hasConceptScore W3174229932C2776504411 @default.
- W3174229932 hasConceptScore W3174229932C2776885963 @default.
- W3174229932 hasConceptScore W3174229932C2777676773 @default.
- W3174229932 hasConceptScore W3174229932C2778186239 @default.
- W3174229932 hasConceptScore W3174229932C2778938600 @default.
- W3174229932 hasConceptScore W3174229932C2781161787 @default.
- W3174229932 hasConceptScore W3174229932C57236427 @default.
- W3174229932 hasConceptScore W3174229932C71924100 @default.
- W3174229932 hasConceptScore W3174229932C86803240 @default.
- W3174229932 hasFunder F4320332161 @default.
- W3174229932 hasIssue "4" @default.
- W3174229932 hasLocation W31742299321 @default.
- W3174229932 hasOpenAccess W3174229932 @default.
- W3174229932 hasPrimaryLocation W31742299321 @default.
- W3174229932 hasRelatedWork W1969416354 @default.
- W3174229932 hasRelatedWork W2033222714 @default.
- W3174229932 hasRelatedWork W2033768432 @default.
- W3174229932 hasRelatedWork W2058169953 @default.
- W3174229932 hasRelatedWork W2078895783 @default.
- W3174229932 hasRelatedWork W2091195494 @default.
- W3174229932 hasRelatedWork W2577349890 @default.
- W3174229932 hasRelatedWork W2766852629 @default.
- W3174229932 hasRelatedWork W2989716236 @default.
- W3174229932 hasRelatedWork W4245157172 @default.
- W3174229932 hasVolume "20" @default.
- W3174229932 isParatext "false" @default.
- W3174229932 isRetracted "false" @default.
- W3174229932 magId "3174229932" @default.
- W3174229932 workType "article" @default.