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- W3174232859 endingPage "6846" @default.
- W3174232859 startingPage "6846" @default.
- W3174232859 abstract "Several studies indicate that semen quality has strongly declined in the last decades worldwide. Air pollution represents a significant co-factor with the COVID-19 impact and has negative effects on the male reproductive system, through pro-oxidant, inflammatory and immune-dysregulating mechanisms. It has recently been reported that chronic exposure to PM2.5 causes overexpression of the alveolar ACE2 receptor, the entry route of SARS-CoV-2 into the organism shared by the lungs and testis where expression is highest in the body. In the testis, the ACE2/Ang-(1–7)/MasR pathway plays an important role in the regulation of spermatogenesis and an indirect mechanism of testicular damage could be due to the blockade of the ACE2 receptor by SARS-CoV-2. This prevents the conversion of specific angiotensins, and their excess causes inflammation with the overproduction of cytokines. PM2.5-induced overexpression of the alveolar ACE2 receptor, in turn, could increase local viral load in patients exposed to pollutants, producing ACE2 receptor depletion and compromising host defenses. By presenting an overall view of epidemiological data and molecular mechanisms, this manuscript aims to interpret the possible synergistic effects of both air pollution and COVID-19 on male reproductive function, warning that the spread of SARS-CoV-2 in the fertile years may represent a significant threat to global reproductive health. All of this should be of great concern, especially for men of the age of maximum reproductive capacity, and an important topic of debate for policy makers. Altered environmental conditions, together with the direct and indirect short- and long-term effects of viral infection could cause a worsening of semen quality with important consequences for male fertility, especially in those areas with higher environmental impact." @default.
- W3174232859 created "2021-07-05" @default.
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- W3174232859 date "2021-06-25" @default.
- W3174232859 modified "2023-09-26" @default.
- W3174232859 title "Air Pollution and COVID-19: A Possible Dangerous Synergy for Male Fertility" @default.
- W3174232859 cites W1044927166 @default.
- W3174232859 cites W1488537470 @default.
- W3174232859 cites W1542568396 @default.
- W3174232859 cites W1892219175 @default.
- W3174232859 cites W1977553423 @default.
- W3174232859 cites W1979238441 @default.
- W3174232859 cites W1996311210 @default.
- W3174232859 cites W1998964868 @default.
- W3174232859 cites W1999754300 @default.
- W3174232859 cites W2003877200 @default.
- W3174232859 cites W2013167930 @default.
- W3174232859 cites W2017263419 @default.
- W3174232859 cites W2018168728 @default.
- W3174232859 cites W2028082228 @default.
- W3174232859 cites W2032042687 @default.
- W3174232859 cites W2032743237 @default.
- W3174232859 cites W2033767295 @default.
- W3174232859 cites W2034909708 @default.
- W3174232859 cites W2045940080 @default.
- W3174232859 cites W2069562377 @default.
- W3174232859 cites W2077140741 @default.
- W3174232859 cites W2087340528 @default.
- W3174232859 cites W2092695614 @default.
- W3174232859 cites W2105065756 @default.
- W3174232859 cites W2105628448 @default.
- W3174232859 cites W2110488501 @default.
- W3174232859 cites W2111485149 @default.
- W3174232859 cites W2114336570 @default.
- W3174232859 cites W2120664210 @default.
- W3174232859 cites W2124356353 @default.
- W3174232859 cites W2134765601 @default.
- W3174232859 cites W2135791851 @default.
- W3174232859 cites W2139348997 @default.
- W3174232859 cites W2141390557 @default.
- W3174232859 cites W2144292929 @default.
- W3174232859 cites W2148658155 @default.
- W3174232859 cites W2150553459 @default.
- W3174232859 cites W2151300926 @default.
- W3174232859 cites W2163067702 @default.
- W3174232859 cites W2166893883 @default.
- W3174232859 cites W2168301383 @default.
- W3174232859 cites W2195173326 @default.
- W3174232859 cites W2337336324 @default.
- W3174232859 cites W2516510481 @default.
- W3174232859 cites W2524237023 @default.
- W3174232859 cites W2538474177 @default.
- W3174232859 cites W2626224371 @default.
- W3174232859 cites W2727630201 @default.
- W3174232859 cites W2736368078 @default.
- W3174232859 cites W2739446247 @default.
- W3174232859 cites W2741412919 @default.
- W3174232859 cites W2744859136 @default.
- W3174232859 cites W2747066332 @default.
- W3174232859 cites W2757939858 @default.
- W3174232859 cites W2767658497 @default.
- W3174232859 cites W2768671952 @default.
- W3174232859 cites W2768967814 @default.
- W3174232859 cites W2788021808 @default.
- W3174232859 cites W2789879951 @default.
- W3174232859 cites W2790191901 @default.
- W3174232859 cites W2791708939 @default.
- W3174232859 cites W2794998024 @default.
- W3174232859 cites W2799518319 @default.
- W3174232859 cites W2799856742 @default.
- W3174232859 cites W2808225226 @default.
- W3174232859 cites W2808244690 @default.
- W3174232859 cites W2810726927 @default.
- W3174232859 cites W2895909191 @default.
- W3174232859 cites W2896656730 @default.
- W3174232859 cites W2899477564 @default.
- W3174232859 cites W2903288046 @default.
- W3174232859 cites W2903883973 @default.
- W3174232859 cites W2906709421 @default.
- W3174232859 cites W2911095316 @default.
- W3174232859 cites W2939114139 @default.
- W3174232859 cites W2942281532 @default.
- W3174232859 cites W2944180707 @default.
- W3174232859 cites W2965941796 @default.
- W3174232859 cites W2966851786 @default.
- W3174232859 cites W2972773858 @default.
- W3174232859 cites W2972809128 @default.
- W3174232859 cites W2975994788 @default.
- W3174232859 cites W2981657433 @default.
- W3174232859 cites W2982078978 @default.
- W3174232859 cites W2998467315 @default.