FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174276989> ?p ?o ?g. }

• W3174276989 endingPage "6665" @default.
• W3174276989 startingPage "6665" @default.
• W3174276989 abstract "Key features of chronic lymphocytic leukemia (CLL) are defects in the immune system and the ability of leukemic cells to evade immune defenses and induce immunosuppression, resulting in increased susceptibility to infections and disease progression. Several immune effectors are impaired in CLL, including T and natural killer (NK) cells. The role of T cells in defense against CLL and in CLL progression and immunotherapy has been extensively studied. Less is known about the role of NK cells in this leukemia, and data on NK cell alterations in CLL are contrasting. Besides studies showing that NK cells have intrinsic defects in CLL, there is a large body of evidence indicating that NK cell dysfunctions in CLL mainly depend on the escape mechanisms employed by leukemic cells. In keeping, it has been shown that NK cell functions, including antibody-dependent cellular cytotoxicity (ADCC), can be retained and/or restored after adequate stimulation. Therefore, due to their preserved ADCC function and the reversibility of CLL-related dysfunctions, NK cells are an attractive source for novel immunotherapeutic strategies in this disease, including chimeric antigen receptor (CAR) therapy. Recently, satisfying clinical responses have been obtained in CLL patients using cord blood-derived CAR-NK cells, opening new possibilities for further exploring NK cells in the immunotherapy of CLL. However, notwithstanding the promising results of this clinical trial, more evidence is needed to fully understand whether and in which CLL cases NK cell-based immunotherapy may represent a valid, alternative/additional therapeutic option for this leukemia. In this review, we provide an overview of the current knowledge about phenotypic and functional alterations of NK cells in CLL and the mechanisms by which CLL cells circumvent NK cell-mediated immunosurveillance. Additionally, we discuss the potential relevance of using NK cells in CLL immunotherapy." @default.
• W3174276989 created "2021-07-05" @default.
• W3174276989 creator A5019164828 @default.
• W3174276989 creator A5036115192 @default.
• W3174276989 creator A5040151837 @default.
• W3174276989 creator A5044293679 @default.
• W3174276989 creator A5049239860 @default.
• W3174276989 creator A5053385325 @default.
• W3174276989 creator A5054685615 @default.
• W3174276989 creator A5055489008 @default.
• W3174276989 creator A5063800776 @default.
• W3174276989 creator A5068281315 @default.
• W3174276989 creator A5068316536 @default.
• W3174276989 creator A5084332214 @default.
• W3174276989 date "2021-06-22" @default.
• W3174276989 modified "2023-09-23" @default.
• W3174276989 title "NK Cells in Chronic Lymphocytic Leukemia and Their Therapeutic Implications" @default.
• W3174276989 cites W127707871 @default.
• W3174276989 cites W1524742538 @default.
• W3174276989 cites W1532384917 @default.
• W3174276989 cites W1535201796 @default.
• W3174276989 cites W1538826344 @default.
• W3174276989 cites W1721974233 @default.
• W3174276989 cites W1763646533 @default.
• W3174276989 cites W1796843950 @default.
• W3174276989 cites W1904332237 @default.
• W3174276989 cites W1945522870 @default.
• W3174276989 cites W1955625177 @default.
• W3174276989 cites W1964265426 @default.
• W3174276989 cites W1964982854 @default.
• W3174276989 cites W1965159977 @default.
• W3174276989 cites W1966016310 @default.
• W3174276989 cites W1968488884 @default.
• W3174276989 cites W1969950463 @default.
• W3174276989 cites W1970312642 @default.
• W3174276989 cites W1974036792 @default.
• W3174276989 cites W1974917518 @default.
• W3174276989 cites W1981624147 @default.
• W3174276989 cites W1984515197 @default.
• W3174276989 cites W1985565700 @default.
• W3174276989 cites W1987794483 @default.
• W3174276989 cites W1988224733 @default.
• W3174276989 cites W1989712520 @default.
• W3174276989 cites W1992079585 @default.
• W3174276989 cites W1992508362 @default.
• W3174276989 cites W1994875855 @default.
• W3174276989 cites W1996787721 @default.
• W3174276989 cites W1996891899 @default.
• W3174276989 cites W2000639623 @default.
• W3174276989 cites W2001970096 @default.
• W3174276989 cites W2002982888 @default.
• W3174276989 cites W2003912772 @default.
• W3174276989 cites W2005680325 @default.
• W3174276989 cites W2006608981 @default.
• W3174276989 cites W2007400263 @default.
• W3174276989 cites W2008919922 @default.
• W3174276989 cites W2009872043 @default.
• W3174276989 cites W2012501889 @default.
• W3174276989 cites W2014144836 @default.
• W3174276989 cites W2016042196 @default.
• W3174276989 cites W2016056988 @default.
• W3174276989 cites W2018244870 @default.
• W3174276989 cites W2018642917 @default.
• W3174276989 cites W2018756833 @default.
• W3174276989 cites W2019813857 @default.
• W3174276989 cites W2020586896 @default.
• W3174276989 cites W2024183493 @default.
• W3174276989 cites W2024292448 @default.
• W3174276989 cites W2024576329 @default.
• W3174276989 cites W2026859850 @default.
• W3174276989 cites W2028072991 @default.
• W3174276989 cites W2028091596 @default.
• W3174276989 cites W2039638023 @default.
• W3174276989 cites W2040040334 @default.
• W3174276989 cites W2040809972 @default.
• W3174276989 cites W2040935430 @default.
• W3174276989 cites W2041953257 @default.
• W3174276989 cites W2044360617 @default.
• W3174276989 cites W2044435667 @default.
• W3174276989 cites W2046271789 @default.
• W3174276989 cites W2051103323 @default.
• W3174276989 cites W2051491397 @default.
• W3174276989 cites W2051549641 @default.
• W3174276989 cites W2052336384 @default.
• W3174276989 cites W2054420591 @default.
• W3174276989 cites W2054499416 @default.
• W3174276989 cites W2057038077 @default.
• W3174276989 cites W2062733828 @default.
• W3174276989 cites W2066082105 @default.
• W3174276989 cites W2068335535 @default.
• W3174276989 cites W2075736621 @default.
• W3174276989 cites W2075869497 @default.
• W3174276989 cites W2076118435 @default.
• W3174276989 cites W2079502160 @default.
• W3174276989 cites W2083289662 @default.
• W3174276989 cites W2083362831 @default.
• W3174276989 cites W2084896925 @default.
• W3174276989 cites W2088513299 @default.

• next