FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174289803> ?p ?o ?g. }

• W3174289803 abstract "Introduction: The Elderly Prognostic Index (EPI) is based on the integration of a simplified geriatric assessment (sGA), haemoglobin levels, and International Prognostic Index (IPI) and has been validated to predict overall survival in older patients with Diffuse Large B-cell lymphoma (DLBCL) (Merli et al, JCO 2021). In this study we evaluated the ability of EPI to predict the risk of early mortality in older DLBCL patients. Methods: This analysis was conducted starting from the same dataset of the prospective observational Elderly Project (EP) that has been used to define the EPI. The main endpoint of this analysis was early mortality rate defined as death occurring within 90 days from the date of diagnosis. Starting from EP we only excluded alive patients with a follow-up shorter than 90 days. Clinical features, treatment details, and causes of death were retrieved from the EP dataset. Treatment was classified in three groups: Full Dose (FD; > 70% of theoretical dose of anthracycline), Reduced Dose (RD; < 70%), and Palliative therapy (PT; No anthracyclines). EPI was calculated as originally reported (Merli et al. JCO 2021) (Figure 1A). Results: This study was conducted on 1150 out of 1163 patients retrieved from the EP who were evaluable for the type of therapy and follow-up. Median age was 76 years (65 to 94). Thirty-one percent were older than 80 years; 55%, 28% and 17% were FIT, UNFIT , and FRAIL based on sGA. EPI score was 0-1 (low), 2-5 (intermediate), and 6-8 (high) in 24%, 48% and 28%, respectively. Time to Therapy (TTT) was shorter than 15 days in 24%. A pre-phase therapy was administered in 14% of patients but details were lacking. Overall, 69 early deaths were observed being 19% of all reported deaths. The cumulative incidence of early death at 90 days was 6.0%. Comparing the causes of the deaths occurring earlier or later than 90 days we observed lower frequency of deaths due to lymphoma progression for early events (42% vs 75%) and higher frequency of deaths due to toxicity and to infections (32% vs 4% and 22% vs 3%, respectively). In univariable analysis factors associated with higher risk of early deaths were age >80 years, sGA, anemia, high risk IPI, TTT < 15 days, bulky disease, EPI (intermediate and high risk) and the use of PT. We conducted a multivariable analysis on 931 patients excluding PT and confirmed an independent prognostic role to predict Early death for high risk EPI (OR 3.45; 95% CI 1.07–11.2) (Figure 1B) and for bulky disease (OR 2.09; 95% CI 1.09 – 3.98) The research was funded by: GRADE non profit foundation and UniCredit Bank Keywords: Diagnostic and Prognostic Biomarkers, Aggressive B-cell non-Hodgkin lymphoma, Therapeutics and Clinical Trials in Lymphoma - Other No conflicts of interest pertinent to the abstract." @default.
• W3174289803 created "2021-07-05" @default.
• W3174289803 creator A5001532055 @default.
• W3174289803 creator A5003717779 @default.
• W3174289803 creator A5005592897 @default.
• W3174289803 creator A5006816146 @default.
• W3174289803 creator A5006828974 @default.
• W3174289803 creator A5008194314 @default.
• W3174289803 creator A5008504309 @default.
• W3174289803 creator A5011759794 @default.
• W3174289803 creator A5012645361 @default.
• W3174289803 creator A5015128036 @default.
• W3174289803 creator A5016803459 @default.
• W3174289803 creator A5017472528 @default.
• W3174289803 creator A5018106127 @default.
• W3174289803 creator A5022084256 @default.
• W3174289803 creator A5024161871 @default.
• W3174289803 creator A5034807520 @default.
• W3174289803 creator A5037995377 @default.
• W3174289803 creator A5039845542 @default.
• W3174289803 creator A5040899311 @default.
• W3174289803 creator A5041169669 @default.
• W3174289803 creator A5042513487 @default.
• W3174289803 creator A5045464407 @default.
• W3174289803 creator A5045601117 @default.
• W3174289803 creator A5049019689 @default.
• W3174289803 creator A5052973923 @default.
• W3174289803 creator A5055668981 @default.
• W3174289803 creator A5059060009 @default.
• W3174289803 creator A5061012594 @default.
• W3174289803 creator A5061188476 @default.
• W3174289803 creator A5063675719 @default.
• W3174289803 creator A5065443409 @default.
• W3174289803 creator A5066201212 @default.
• W3174289803 creator A5070003191 @default.
• W3174289803 creator A5070490189 @default.
• W3174289803 creator A5074069337 @default.
• W3174289803 creator A5074795646 @default.
• W3174289803 creator A5076236981 @default.
• W3174289803 creator A5081879832 @default.
• W3174289803 creator A5082964368 @default.
• W3174289803 creator A5085955672 @default.
• W3174289803 creator A5089632360 @default.
• W3174289803 date "2021-06-01" @default.
• W3174289803 modified "2023-09-30" @default.
• W3174289803 title "THE ELDERLY PROGNOSTIC INDEX (EPI) PREDICTS EARLY MORTALITY IN OLDER PATIENTS WITH DLBCL. A SUBSTUDY OF THE ELDERLY PROJECT BY THE FONDAZIONE ITALIANA LINFOMI (FIL)" @default.
• W3174289803 doi "https://doi.org/10.1002/hon.85_2880" @default.
• W3174289803 hasPublicationYear "2021" @default.
• W3174289803 type Work @default.
• W3174289803 sameAs 3174289803 @default.
• W3174289803 citedByCount "0" @default.
• W3174289803 crossrefType "journal-article" @default.
• W3174289803 hasAuthorship W3174289803A5001532055 @default.
• W3174289803 hasAuthorship W3174289803A5003717779 @default.
• W3174289803 hasAuthorship W3174289803A5005592897 @default.
• W3174289803 hasAuthorship W3174289803A5006816146 @default.
• W3174289803 hasAuthorship W3174289803A5006828974 @default.
• W3174289803 hasAuthorship W3174289803A5008194314 @default.
• W3174289803 hasAuthorship W3174289803A5008504309 @default.
• W3174289803 hasAuthorship W3174289803A5011759794 @default.
• W3174289803 hasAuthorship W3174289803A5012645361 @default.
• W3174289803 hasAuthorship W3174289803A5015128036 @default.
• W3174289803 hasAuthorship W3174289803A5016803459 @default.
• W3174289803 hasAuthorship W3174289803A5017472528 @default.
• W3174289803 hasAuthorship W3174289803A5018106127 @default.
• W3174289803 hasAuthorship W3174289803A5022084256 @default.
• W3174289803 hasAuthorship W3174289803A5024161871 @default.
• W3174289803 hasAuthorship W3174289803A5034807520 @default.
• W3174289803 hasAuthorship W3174289803A5037995377 @default.
• W3174289803 hasAuthorship W3174289803A5039845542 @default.
• W3174289803 hasAuthorship W3174289803A5040899311 @default.
• W3174289803 hasAuthorship W3174289803A5041169669 @default.
• W3174289803 hasAuthorship W3174289803A5042513487 @default.
• W3174289803 hasAuthorship W3174289803A5045464407 @default.
• W3174289803 hasAuthorship W3174289803A5045601117 @default.
• W3174289803 hasAuthorship W3174289803A5049019689 @default.
• W3174289803 hasAuthorship W3174289803A5052973923 @default.
• W3174289803 hasAuthorship W3174289803A5055668981 @default.
• W3174289803 hasAuthorship W3174289803A5059060009 @default.
• W3174289803 hasAuthorship W3174289803A5061012594 @default.
• W3174289803 hasAuthorship W3174289803A5061188476 @default.
• W3174289803 hasAuthorship W3174289803A5063675719 @default.
• W3174289803 hasAuthorship W3174289803A5065443409 @default.
• W3174289803 hasAuthorship W3174289803A5066201212 @default.
• W3174289803 hasAuthorship W3174289803A5070003191 @default.
• W3174289803 hasAuthorship W3174289803A5070490189 @default.
• W3174289803 hasAuthorship W3174289803A5074069337 @default.
• W3174289803 hasAuthorship W3174289803A5074795646 @default.
• W3174289803 hasAuthorship W3174289803A5076236981 @default.
• W3174289803 hasAuthorship W3174289803A5081879832 @default.
• W3174289803 hasAuthorship W3174289803A5082964368 @default.
• W3174289803 hasAuthorship W3174289803A5085955672 @default.
• W3174289803 hasAuthorship W3174289803A5089632360 @default.
• W3174289803 hasBestOaLocation W31742898031 @default.
• W3174289803 hasConcept C121608353 @default.
• W3174289803 hasConcept C126322002 @default.
• W3174289803 hasConcept C203092338 @default.
• W3174289803 hasConcept C23131810 @default.
• W3174289803 hasConcept C2776802502 @default.
• W3174289803 hasConcept C2778476033 @default.

• next