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• W3174291913 endingPage "102735" @default.
• W3174291913 startingPage "102735" @default.
• W3174291913 abstract "Diffuse low-grade gliomas (DLGG) display different preferential locations in eloquent and secondary associative brain areas. The reason for this tendency is still unknown. We hypothesized that the intrinsic architecture and water diffusion properties of the white matter bundles in these regions may facilitate gliomas infiltration. Magnetic resonance imaging of sixty-seven diffuse low-grade gliomas patients were normalized to/and segmented in MNI space to create three probabilistic infiltration weighted gradient maps according to the molecular status of each tumor group (IDH mutated, IDH wild-type and IDH mutated/1p19q co-deleted). Diffusion tensor imaging (DTI)- based parameters were derived for five major white matter bundles, displaying regional differences in the grade of infiltration, averaged over 20 healthy individuals acquired from the Human connectome project (HCP) database. Transmission electron microscopy (TEM) was used to analyze fiber density, fiber diameter and g-ratio in 100 human white matter regions, sampled from cadaver specimens, reflecting areas with different gliomas infiltration in each white matter bundle. Histological results and DTI-based parameters were compared in anatomical regions of high- and low grade of infiltration (HIF and LIF) respectively. We detected differences in the white matter infiltration of five major white matter bundles in three groups. Astrocytomas IDHm infiltrated left fronto-temporal subcortical areas. Astrocytomas IDHwt were detected in the posterior-temporal and temporo-parietal regions bilaterally. Oligodendrogliomas IDHm/1p19q infiltrated anterior subcortical regions of the frontal lobes bilaterally. Regional differences within the same white matter bundles were detected by both TEM- and DTI analysis linked to different topographical variables. Our multimodal analysis showed that HIF regions, common to all the groups, displayed a smaller fiber diameter, lower FA and higher RD compared with LIF regions. Our results suggest that the both morphological features and diffusion parameters of the white matter may be different in regions linked to the preferential location of DLGG." @default.
• W3174291913 created "2021-07-05" @default.
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• W3174291913 date "2021-01-01" @default.
• W3174291913 modified "2023-10-16" @default.
• W3174291913 title "The link between gliomas infiltration and white matter architecture investigated with electron microscopy and diffusion tensor imaging" @default.
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• W3174291913 doi "https://doi.org/10.1016/j.nicl.2021.102735" @default.
• W3174291913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8274339" @default.
• W3174291913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34247117" @default.
• W3174291913 hasPublicationYear "2021" @default.
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