Matches in SemOpenAlex for { <https://semopenalex.org/work/W3174295200> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3174295200 abstract "Abstract Dehydropeptidase-1 ( DPEP1 ) is a zinc-dependent metalloproteinase abnormally expressed in many cancers. However, its potential role in adults with B-cell acute lymphoblastic leukaemia (ALL) is unknown. We found that in adults with common-B-cell ALL high DPEP1 transcript levels at diagnosis was independently-associated with an increased CIR and worse RFS compared with subjects with low transcript levels. We show an increased proliferation and pro-survival role of DPEP1 in B-cell ALL cells via regulation of phosphCREB and p53 which may be the biological basis of the clinical correlation we report. Our data implicate DPEP1 expression in the biology of common B-cell ALL in adults. We report clinical correlates and provide a potential biological basis for these correlations. If confirmed, analyzing DPEP1 transcript levels at diagnosis could help predict therapy-outcomes. Moreover, regulation of DPEP1 expression could be a therapy target in B-cell ALL." @default.
- W3174295200 created "2021-07-05" @default.
- W3174295200 creator A5006083381 @default.
- W3174295200 creator A5011029344 @default.
- W3174295200 creator A5016322565 @default.
- W3174295200 creator A5018570419 @default.
- W3174295200 creator A5041024027 @default.
- W3174295200 creator A5042895806 @default.
- W3174295200 creator A5055352258 @default.
- W3174295200 creator A5061079851 @default.
- W3174295200 creator A5061925043 @default.
- W3174295200 creator A5063278451 @default.
- W3174295200 creator A5064132181 @default.
- W3174295200 creator A5064154049 @default.
- W3174295200 creator A5067670661 @default.
- W3174295200 creator A5069469021 @default.
- W3174295200 creator A5075224835 @default.
- W3174295200 creator A5088917859 @default.
- W3174295200 creator A5088980736 @default.
- W3174295200 date "2019-08-21" @default.
- W3174295200 modified "2023-09-26" @default.
- W3174295200 title "The Clinical Significance and Biological Function ofDPEP1in B-cell Acute Lymphoblastic Leukemia" @default.
- W3174295200 cites W1784814409 @default.
- W3174295200 cites W1967269413 @default.
- W3174295200 cites W1972431219 @default.
- W3174295200 cites W1975127056 @default.
- W3174295200 cites W1982247089 @default.
- W3174295200 cites W1984826290 @default.
- W3174295200 cites W1985540489 @default.
- W3174295200 cites W1993782263 @default.
- W3174295200 cites W2007886976 @default.
- W3174295200 cites W2010328447 @default.
- W3174295200 cites W2014982421 @default.
- W3174295200 cites W2036862498 @default.
- W3174295200 cites W2084001039 @default.
- W3174295200 cites W2141324982 @default.
- W3174295200 cites W2141696179 @default.
- W3174295200 cites W2153747194 @default.
- W3174295200 cites W2227253169 @default.
- W3174295200 cites W2272159258 @default.
- W3174295200 cites W2290380888 @default.
- W3174295200 cites W2303834781 @default.
- W3174295200 cites W2338718341 @default.
- W3174295200 cites W2342982720 @default.
- W3174295200 cites W2396128094 @default.
- W3174295200 cites W2599308060 @default.
- W3174295200 cites W4296004058 @default.
- W3174295200 doi "https://doi.org/10.1101/742551" @default.
- W3174295200 hasPublicationYear "2019" @default.
- W3174295200 type Work @default.
- W3174295200 sameAs 3174295200 @default.
- W3174295200 citedByCount "0" @default.
- W3174295200 crossrefType "posted-content" @default.
- W3174295200 hasAuthorship W3174295200A5006083381 @default.
- W3174295200 hasAuthorship W3174295200A5011029344 @default.
- W3174295200 hasAuthorship W3174295200A5016322565 @default.
- W3174295200 hasAuthorship W3174295200A5018570419 @default.
- W3174295200 hasAuthorship W3174295200A5041024027 @default.
- W3174295200 hasAuthorship W3174295200A5042895806 @default.
- W3174295200 hasAuthorship W3174295200A5055352258 @default.
- W3174295200 hasAuthorship W3174295200A5061079851 @default.
- W3174295200 hasAuthorship W3174295200A5061925043 @default.
- W3174295200 hasAuthorship W3174295200A5063278451 @default.
- W3174295200 hasAuthorship W3174295200A5064132181 @default.
- W3174295200 hasAuthorship W3174295200A5064154049 @default.
- W3174295200 hasAuthorship W3174295200A5067670661 @default.
- W3174295200 hasAuthorship W3174295200A5069469021 @default.
- W3174295200 hasAuthorship W3174295200A5075224835 @default.
- W3174295200 hasAuthorship W3174295200A5088917859 @default.
- W3174295200 hasAuthorship W3174295200A5088980736 @default.
- W3174295200 hasBestOaLocation W31742952001 @default.
- W3174295200 hasConcept C14036430 @default.
- W3174295200 hasConcept C203014093 @default.
- W3174295200 hasConcept C2778461978 @default.
- W3174295200 hasConcept C2909962599 @default.
- W3174295200 hasConcept C502942594 @default.
- W3174295200 hasConcept C54355233 @default.
- W3174295200 hasConcept C71924100 @default.
- W3174295200 hasConcept C86803240 @default.
- W3174295200 hasConceptScore W3174295200C14036430 @default.
- W3174295200 hasConceptScore W3174295200C203014093 @default.
- W3174295200 hasConceptScore W3174295200C2778461978 @default.
- W3174295200 hasConceptScore W3174295200C2909962599 @default.
- W3174295200 hasConceptScore W3174295200C502942594 @default.
- W3174295200 hasConceptScore W3174295200C54355233 @default.
- W3174295200 hasConceptScore W3174295200C71924100 @default.
- W3174295200 hasConceptScore W3174295200C86803240 @default.
- W3174295200 hasLocation W31742952001 @default.
- W3174295200 hasOpenAccess W3174295200 @default.
- W3174295200 hasPrimaryLocation W31742952001 @default.
- W3174295200 isParatext "false" @default.
- W3174295200 isRetracted "false" @default.
- W3174295200 magId "3174295200" @default.
- W3174295200 workType "article" @default.