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- W3174306721 abstract "This study evaluated if aerobic training (AT) improves glomerular morphology in hypertensive (SHR) and normotensive (WKY) rats. We used SHR and WKY male rats 10weeks-age submitted or not to AT (1hr, 5 times/week) for 1, 2, 4, 8 and 12 weeks or kept sedentary for 0 and 12 weeks (n=8/each). Mean arterial pressure (MAP) and heart rate (HR) were recorded, and kidneys harvested for Bowmanˈs capsule (BC) evaluation. Results were compared by ANOVA, using p=0.05 as significant. Both WKY and SHR improved physical performance after 6 and 12 weeks of AT(S0:1.02±0.3 vs 1.62±0.4, T6:1.32±0.2 vs 2.09±0.3, T12:1.92±0.4 vs 2.40±0.4km/h). SHR decreased MAP and HR (179±10 vs 163±6mmHg, 394±18 vs 363±3bpm; on S0 vs T12). BC thickness showed greater deposition of collagen fibers in SHR compared to WKY (3.72±1.35 vs 1.98±0.25?m; on sedentary), and reduction after AT in SHR (1.79±0.24μm). Proteoglycan analysis showed an increased deposition induced by hypertension (1.34±0.41 vs 0.90±0.09μm; sedentary SHR vs WKY), and AT decreased this in both(SHR:1.34±0.41 vs 0.75±0.09μm, WKY:0.90±0.09 vs 0.65±0.02μm; S0 vs T12). We also observed that the time of hypertension increases deposition of proteoglycans (1.34±0.41 vs 1.64±0.48μm; S0 vs S12). The data suggest that AT induces glomerular remodeling, reducing glomerular fibrosis and glomerulosclerosis in SHR, and may be associated with the observed fall in MAP. Grant Funding Source : FAPESP" @default.
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- W3174306721 date "2012-04-01" @default.
- W3174306721 modified "2023-09-27" @default.
- W3174306721 title "Effect of aerobic training on the deposition of collagen fibers and glomerular proteoglycans in hypertensive rats" @default.
- W3174306721 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1138.16" @default.
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