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- W3174318475 abstract "Eosinophils are important in the pathophysiology of allergic diseases and in host immunity. Although microorganisms directly activate inflammatory cells, the mechanisms that trigger eosinophils activation and its functions in immune responses are unknown. Fungi are ubiquitous and may contribute to the development and exacerbation of pulmonary diseases. In this sense, the aim of this study was to unravel the role of eosinophils during Aspergillus fumigatus lung infection. Wild type (BALB/c) and ΔdblGATA mice were infected intranasally with 108 spores of an A. fumigatus wild type strain. Results show that ΔdblGATA mice had increased survival (40% versus 100% in WT mice). PMN influx in the lungs (1dpi) and airways (3 dpi) were greater in ΔdblGATA mice, but there was less protein leakage (3 dpi). Levels of eosinophils were very high in lungs and airways of WT mice after A. fumigatus infection but not detectable in ΔdblGATA mice. Airway levels of CXCL1, TNF-α, CCL11, CCL2 and IL-1β were reduced in ΔdblGATA mice. Interestingly, histopathological analysis did not show any differences between animals. Fungal burden was higher in ΔdblGATA mice than WT mice after 1 and 3 dpi. In conclusion, the absence of eosinophils leads to decreased production of key cytokines and increased fungal burden after infection with A. fumigatus. However, this is associated with enhanced neutrophil influx and survival, suggesting that eosinophils are crucial in setting the appropriate tone of the immune response to infection by A. fumigatus. Financial Support: CNPq, Capes, FAPEMIG." @default.
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- W3174318475 date "2012-04-01" @default.
- W3174318475 modified "2023-09-25" @default.
- W3174318475 title "The Role of Eosinophils in Aspergillus fumigatus Lung Infection" @default.
- W3174318475 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1119.5" @default.
- W3174318475 hasPublicationYear "2012" @default.
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